STRINGSTRING
PRKCA PRKCA ATM ATM CDK4 CDK4 PTEN PTEN CHD4 CHD4 BRCA1 BRCA1 FRS2 FRS2 CYP19A1 CYP19A1 TP53 TP53 BCL11B BCL11B PIK3CA PIK3CA H3B8U3_LATCH H3B8U3_LATCH MTOR MTOR KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (577 aa)
ATMATM serine/threonine kinase. (2375 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
CHD4Chromodomain helicase DNA binding protein 4a. (1669 aa)
BRCA1BRCA1 DNA repair associated. (1873 aa)
FRS2Fibroblast growth factor receptor substrate 2. (502 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1. (443 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B a. (114 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
H3B8U3_LATCHSerine/threonine-protein kinase TOR. (1418 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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