(53 nodes) (2020) Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm. network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	UCP2	Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	H3F3B	Histone H3; Belongs to the histone H3 family. (136 aa)
	TBC1D1	TBC1 domain family member 1. (431 aa)
	NAPEPLD	N-acyl phosphatidylethanolamine phospholipase D. (263 aa)
	CRTC2	CREB regulated transcription coactivator 2. (691 aa)
	NAMPT	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (492 aa)
	ECHS1	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (468 aa)
	STAT1	Signal transducer and activator of transcription. (1179 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (310 aa)
	SIRT6	Sirtuin 6. (375 aa)
	SIRT1	Sirtuin 1. (729 aa)
	CRY1	Cryptochrome circadian regulator 1. (653 aa)
	IL6	Uncharacterized protein. (149 aa)
	LOC102355712	Histone H3; Belongs to the histone H3 family. (129 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (590 aa)
	PYGB	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (267 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
	FOXO1	Forkhead box O1. (633 aa)
	NOTUM	Notum, palmitoleoyl-protein carboxylesterase. (506 aa)
	ACSL5	Acyl-CoA synthetase long chain family member 5. (683 aa)
	NPAS2	Neuronal PAS domain protein 2. (818 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (1016 aa)
	H3F3B-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	GHRL	Motilin_assoc domain-containing protein. (110 aa)
	IRS1	Insulin receptor substrate 1. (1076 aa)
	PYY	Peptide YY. (97 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (223 aa)
	IRS2	Insulin receptor substrate 2. (1069 aa)
	NOCT	Nocturnin. (446 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
	GPX3	Glutathione peroxidase 3. (108 aa)
	ACOX1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
	CBL	Cbl proto-oncogene. (903 aa)
	TGFA	Transforming growth factor alpha. (140 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	SIRT4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (315 aa)
	CRY2	Cryptochrome circadian regulator 2. (434 aa)
	AKT2	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (488 aa)
	RETN	Uncharacterized protein. (65 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	TSC2	TSC complex subunit 2. (1836 aa)
	PROK2	Prokineticin 2. (159 aa)
	PER3	Period circadian regulator 3. (1317 aa)
	GYS2	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (705 aa)
	PER2	PAS domain-containing protein. (1371 aa)
	SYNPR-2	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (493 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOX1	ACSL5	ENSLACP00000019825	ENSLACP00000012317	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Acyl-CoA synthetase long chain family member 5.	0.632
ACOX1	CD36	ENSLACP00000019825	ENSLACP00000007631	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	CD36 molecule; Belongs to the CD36 family.	0.549
ACOX1	ECHS1	ENSLACP00000019825	ENSLACP00000005312	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.986
ACOX1	PPARG	ENSLACP00000019825	ENSLACP00000010456	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.642
ACOX1	SOD2	ENSLACP00000019825	ENSLACP00000017629	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.412
ACSL5	ACOX1	ENSLACP00000012317	ENSLACP00000019825	Acyl-CoA synthetase long chain family member 5.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.632
ACSL5	AKT2	ENSLACP00000012317	ENSLACP00000021453	Acyl-CoA synthetase long chain family member 5.	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	0.409
ACSL5	CD36	ENSLACP00000012317	ENSLACP00000007631	Acyl-CoA synthetase long chain family member 5.	CD36 molecule; Belongs to the CD36 family.	0.463
ADIPOQ	CD36	ENSLACP00000000452	ENSLACP00000007631	Adiponectin, C1Q and collagen domain containing.	CD36 molecule; Belongs to the CD36 family.	0.559
ADIPOQ	GHRL	ENSLACP00000000452	ENSLACP00000015917	Adiponectin, C1Q and collagen domain containing.	Motilin_assoc domain-containing protein.	0.542
ADIPOQ	IL6	ENSLACP00000000452	ENSLACP00000009318	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.767
ADIPOQ	IRS1	ENSLACP00000000452	ENSLACP00000016025	Adiponectin, C1Q and collagen domain containing.	Insulin receptor substrate 1.	0.426
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADIPOQ	NAMPT	ENSLACP00000000452	ENSLACP00000005041	Adiponectin, C1Q and collagen domain containing.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.555
ADIPOQ	PPARG	ENSLACP00000000452	ENSLACP00000010456	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.829
ADIPOQ	RETN	ENSLACP00000000452	ENSLACP00000021924	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.889
ADIPOQ	SIRT1	ENSLACP00000000452	ENSLACP00000009079	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.648
AKT2	ACSL5	ENSLACP00000021453	ENSLACP00000012317	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	Acyl-CoA synthetase long chain family member 5.	0.409
AKT2	CBL	ENSLACP00000021453	ENSLACP00000020141	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	Cbl proto-oncogene.	0.543
AKT2	FOXO1	ENSLACP00000021453	ENSLACP00000011598	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	Forkhead box O1.	0.822