(20 nodes) (2020) G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor beta2 in the rat hypothalamic paraventricular nucleus. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102347143	Uncharacterized protein. (612 aa)
	MC4R	Melanocortin 4 receptor. (329 aa)
	CRH	Corticotropin releasing hormone. (166 aa)
	SST	Somatostatin. (118 aa)
	JAK2	Tyrosine-protein kinase. (1152 aa)
	LOC102362951	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	TRHR	Thyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (267 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
	ARNT2	Uncharacterized protein. (206 aa)
	H3ALZ2_LATCH	Uncharacterized protein. (108 aa)
	HDAC3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
	ARNT2-2	Aryl-hydrocarbon receptor nuclear translocator 2. (430 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	PRL	Prolactin. (231 aa)
	KLF10	Kruppel like factor 10. (476 aa)
	SIM1	SIM bHLH transcription factor 1. (460 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (873 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNT2	ARNT2-2	ENSLACP00000010079	ENSLACP00000011352	Uncharacterized protein.	Aryl-hydrocarbon receptor nuclear translocator 2.	0.900
ARNT2	KLF10	ENSLACP00000010079	ENSLACP00000015403	Uncharacterized protein.	Kruppel like factor 10.	0.420
ARNT2	SIM1	ENSLACP00000010079	ENSLACP00000018073	Uncharacterized protein.	SIM bHLH transcription factor 1.	0.825
ARNT2-2	ARNT2	ENSLACP00000011352	ENSLACP00000010079	Aryl-hydrocarbon receptor nuclear translocator 2.	Uncharacterized protein.	0.900
ARNT2-2	KLF10	ENSLACP00000011352	ENSLACP00000015403	Aryl-hydrocarbon receptor nuclear translocator 2.	Kruppel like factor 10.	0.420
ARNT2-2	SIM1	ENSLACP00000011352	ENSLACP00000018073	Aryl-hydrocarbon receptor nuclear translocator 2.	SIM bHLH transcription factor 1.	0.839
CRH	LEP	ENSLACP00000002936	ENSLACP00000011398	Corticotropin releasing hormone.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.552
CRH	MC4R	ENSLACP00000002936	ENSLACP00000000487	Corticotropin releasing hormone.	Melanocortin 4 receptor.	0.568
CRH	PRL	ENSLACP00000002936	ENSLACP00000014482	Corticotropin releasing hormone.	Prolactin.	0.462
CRH	SST	ENSLACP00000002936	ENSLACP00000004014	Corticotropin releasing hormone.	Somatostatin.	0.670
CRH	STAT3	ENSLACP00000002936	ENSLACP00000013656	Corticotropin releasing hormone.	Signal transducer and activator of transcription.	0.554
H3ALZ2_LATCH	JAK2	ENSLACP00000010663	ENSLACP00000006953	Uncharacterized protein.	Tyrosine-protein kinase.	0.571
H3ALZ2_LATCH	LEP	ENSLACP00000010663	ENSLACP00000011398	Uncharacterized protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.422
H3ALZ2_LATCH	MC4R	ENSLACP00000010663	ENSLACP00000000487	Uncharacterized protein.	Melanocortin 4 receptor.	0.463
HDAC3	HDAC4	ENSLACP00000011092	ENSLACP00000008432	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.606
HDAC3	HDAC5	ENSLACP00000011092	ENSLACP00000018356	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.603
HDAC3	HDAC7	ENSLACP00000011092	ENSLACP00000021749	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.627
HDAC3	STAT3	ENSLACP00000011092	ENSLACP00000013656	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Signal transducer and activator of transcription.	0.726
HDAC4	HDAC3	ENSLACP00000008432	ENSLACP00000011092	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.606
HDAC5	HDAC3	ENSLACP00000018356	ENSLACP00000011092	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.603