(29 nodes) (2020) Drug Screening and Drug Repositioning as Promising Therapeutic Approaches for Spinal Muscular Atrophy Treatment. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DCPS	Decapping enzyme, scavenger. (174 aa)
	LOC102345199	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (115 aa)
	UBA1	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1059 aa)
	LOC102362556	Profilin; Belongs to the profilin family. (133 aa)
	GEMIN2	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (265 aa)
	LOC102363280	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (290 aa)
	PFN2	Profilin; Belongs to the profilin family. (140 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
	PLS3	Plastin 3. (630 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (344 aa)
	NCALD	Neurocalcin delta. (193 aa)
	TRH	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (262 aa)
	HDAC3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	FST	Follistatin. (319 aa)
	MSTN	Myostatin. (372 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	LOC102357963	Profilin; Belongs to the profilin family. (140 aa)
	RHOA	Uncharacterized protein. (193 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	CAPN1	Calpain 1; Belongs to the peptidase C2 family. (642 aa)
	AGRN	Agrin. (1882 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (873 aa)
	PFN4	Profilin; Belongs to the profilin family. (128 aa)
	KLF15	Kruppel like factor 15. (400 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	LOC102345199	ENSLACP00000007386	ENSLACP00000001282	Caspase 3; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.854
CASP3	LOC102363280	ENSLACP00000007386	ENSLACP00000005807	Caspase 3; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.907
DCPS	GEMIN2	ENSLACP00000002336	ENSLACP00000005314	Decapping enzyme, scavenger.	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family.	0.555
DCPS	PLS3	ENSLACP00000002336	ENSLACP00000008590	Decapping enzyme, scavenger.	Plastin 3.	0.406
DCPS	UBA1	ENSLACP00000002336	ENSLACP00000002173	Decapping enzyme, scavenger.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.405
FST	MSTN	ENSLACP00000014013	ENSLACP00000017147	Follistatin.	Myostatin.	0.880
FST	TGFB1	ENSLACP00000014013	ENSLACP00000020652	Follistatin.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.499
FST	TGFB3	ENSLACP00000014013	ENSLACP00000018912	Follistatin.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.460
GEMIN2	DCPS	ENSLACP00000005314	ENSLACP00000002336	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family.	Decapping enzyme, scavenger.	0.555
GEMIN2	NCALD	ENSLACP00000005314	ENSLACP00000009655	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family.	Neurocalcin delta.	0.419
GEMIN2	PLS3	ENSLACP00000005314	ENSLACP00000008590	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family.	Plastin 3.	0.444
GEMIN2	UBA1	ENSLACP00000005314	ENSLACP00000002173	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.439
HDAC3	HDAC4	ENSLACP00000011092	ENSLACP00000008432	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.606
HDAC3	HDAC5	ENSLACP00000011092	ENSLACP00000018356	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.603
HDAC3	HDAC7	ENSLACP00000011092	ENSLACP00000021749	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.627
HDAC4	HDAC3	ENSLACP00000008432	ENSLACP00000011092	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.606
HDAC5	HDAC3	ENSLACP00000018356	ENSLACP00000011092	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.603
HDAC7	HDAC3	ENSLACP00000021749	ENSLACP00000011092	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.627
LOC102345199	CASP3	ENSLACP00000001282	ENSLACP00000007386	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase 3; Belongs to the peptidase C14A family.	0.854
LOC102345199	LOC102363280	ENSLACP00000001282	ENSLACP00000005807	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.901