(9 nodes) (2021) Effects of Nutrition Education Program for the Japan Diet on Serum LDL-Cholesterol Concentration in Patients with Dyslipidemia: A Randomized Controlled Trial. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	HK2	Hexokinase 2. (918 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	HK3	Hexokinase 3. (908 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	IL6	Uncharacterized protein. (149 aa)
	HKDC1	Hexokinase domain containing 1. (923 aa)
	HK1	Hexokinase 1. (919 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	H3ACE0_LATCH	ENSLACP00000000452	ENSLACP00000007311	Adiponectin, C1Q and collagen domain containing.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.830
ADIPOQ	IL6	ENSLACP00000000452	ENSLACP00000009318	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.767
ADIPOQ	LEP	ENSLACP00000000452	ENSLACP00000011398	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.952
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
H3ACE0_LATCH	ADIPOQ	ENSLACP00000007311	ENSLACP00000000452	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Adiponectin, C1Q and collagen domain containing.	0.830
H3ACE0_LATCH	HK2	ENSLACP00000007311	ENSLACP00000019265	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Hexokinase 2.	0.417
H3ACE0_LATCH	HK3	ENSLACP00000007311	ENSLACP00000006843	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Hexokinase 3.	0.417
H3ACE0_LATCH	IL6	ENSLACP00000007311	ENSLACP00000009318	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.773
H3ACE0_LATCH	LEP	ENSLACP00000007311	ENSLACP00000011398	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.864
H3ACE0_LATCH	LOC102346019	ENSLACP00000007311	ENSLACP00000019134	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	C1q domain-containing protein.	0.765
HK1	HK2	ENSLACP00000010696	ENSLACP00000019265	Hexokinase 1.	Hexokinase 2.	0.901
HK1	HK3	ENSLACP00000010696	ENSLACP00000006843	Hexokinase 1.	Hexokinase 3.	0.901
HK1	HKDC1	ENSLACP00000010696	ENSLACP00000009710	Hexokinase 1.	Hexokinase domain containing 1.	0.901
HK2	H3ACE0_LATCH	ENSLACP00000019265	ENSLACP00000007311	Hexokinase 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.417
HK2	HK1	ENSLACP00000019265	ENSLACP00000010696	Hexokinase 2.	Hexokinase 1.	0.901
HK2	HK3	ENSLACP00000019265	ENSLACP00000006843	Hexokinase 2.	Hexokinase 3.	0.901
HK2	HKDC1	ENSLACP00000019265	ENSLACP00000009710	Hexokinase 2.	Hexokinase domain containing 1.	0.901
HK3	H3ACE0_LATCH	ENSLACP00000006843	ENSLACP00000007311	Hexokinase 3.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.417
HK3	HK1	ENSLACP00000006843	ENSLACP00000010696	Hexokinase 3.	Hexokinase 1.	0.901
HK3	HK2	ENSLACP00000006843	ENSLACP00000019265	Hexokinase 3.	Hexokinase 2.	0.901