(13 nodes) (2021) Small extracellular vesicles deliver TGF-beta1 and promote adriamycin resistance in breast cancer cells. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NCK1	Cytoplasmic protein. (377 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (589 aa)
	IL10	Interleukin 10. (185 aa)
	LAMB1	Laminin subunit beta 1. (1398 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	TSG101	Tumor susceptibility 101. (392 aa)
	SMAD3	Mothers against decapentaplegic homolog. (358 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (359 aa)
	CANX	Calnexin. (625 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	TWIST1	Twist family bHLH transcription factor 1b. (169 aa)
	CD63	Tetraspanin. (270 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CANX	CD63	ENSLACP00000012732	ENSLACP00000018046	Calnexin.	Tetraspanin.	0.522
CANX	TSG101	ENSLACP00000012732	ENSLACP00000011613	Calnexin.	Tumor susceptibility 101.	0.661
CD63	CANX	ENSLACP00000018046	ENSLACP00000012732	Tetraspanin.	Calnexin.	0.522
CD63	GAPDH	ENSLACP00000018046	ENSLACP00000012705	Tetraspanin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.467
CD63	TSG101	ENSLACP00000018046	ENSLACP00000011613	Tetraspanin.	Tumor susceptibility 101.	0.856
GAPDH	CD63	ENSLACP00000012705	ENSLACP00000018046	Glyceraldehyde-3-phosphate dehydrogenase.	Tetraspanin.	0.467
GAPDH	IL10	ENSLACP00000012705	ENSLACP00000005382	Glyceraldehyde-3-phosphate dehydrogenase.	Interleukin 10.	0.472
GAPDH	STAT3	ENSLACP00000012705	ENSLACP00000013656	Glyceraldehyde-3-phosphate dehydrogenase.	Signal transducer and activator of transcription.	0.513
GAPDH	TSG101	ENSLACP00000012705	ENSLACP00000011613	Glyceraldehyde-3-phosphate dehydrogenase.	Tumor susceptibility 101.	0.487
IL10	GAPDH	ENSLACP00000005382	ENSLACP00000012705	Interleukin 10.	Glyceraldehyde-3-phosphate dehydrogenase.	0.472
IL10	STAT3	ENSLACP00000005382	ENSLACP00000013656	Interleukin 10.	Signal transducer and activator of transcription.	0.821
NCK1	NCK2	ENSLACP00000004112	ENSLACP00000010412	Cytoplasmic protein.	Cytoplasmic protein.	0.970
NCK1	TSG101	ENSLACP00000004112	ENSLACP00000011613	Cytoplasmic protein.	Tumor susceptibility 101.	0.426
NCK2	NCK1	ENSLACP00000010412	ENSLACP00000004112	Cytoplasmic protein.	Cytoplasmic protein.	0.970
NCK2	TSG101	ENSLACP00000010412	ENSLACP00000011613	Cytoplasmic protein.	Tumor susceptibility 101.	0.421
SMAD2	SMAD3	ENSLACP00000008339	ENSLACP00000011989	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
SMAD2	STAT3	ENSLACP00000008339	ENSLACP00000013656	Mothers against decapentaplegic homolog.	Signal transducer and activator of transcription.	0.475
SMAD3	SMAD2	ENSLACP00000011989	ENSLACP00000008339	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
SMAD3	STAT3	ENSLACP00000011989	ENSLACP00000013656	Mothers against decapentaplegic homolog.	Signal transducer and activator of transcription.	0.476
STAT3	GAPDH	ENSLACP00000013656	ENSLACP00000012705	Signal transducer and activator of transcription.	Glyceraldehyde-3-phosphate dehydrogenase.	0.513