STRINGSTRING
GDF3 GDF3 GATA5 GATA5 RIPPLY3 RIPPLY3 WNT4 WNT4 KLF2 KLF2 DHH DHH WNT11 WNT11 HEY2 HEY2 WNT5A WNT5A PITX2 PITX2 IHH IHH LOX LOX EOMES EOMES LMO2 LMO2 SMARCD3 SMARCD3 GATA4 GATA4 LDB1 LDB1 FOSL2 FOSL2 CDH5 CDH5 SHH SHH ISL1 ISL1 FGF3 FGF3 HDAC1 HDAC1 TTN TTN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF3Growth differentiation factor 3. (381 aa)
GATA5GATA binding protein 5. (395 aa)
RIPPLY3Ripply transcriptional repressor 3. (96 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
KLF2Kruppel-like factor 2a. (388 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (424 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (339 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
PITX2Homeobox protein. (314 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
LOXLysyl oxidase. (423 aa)
EOMESEomesodermin. (419 aa)
LMO2LIM domain only 2. (158 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (255 aa)
GATA4GATA binding protein 4. (402 aa)
LDB1LIM domain binding 1. (388 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (332 aa)
CDH5Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
ISL1ISL LIM homeobox 1. (356 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
TTNTitin, tandem duplicate 2. (21846 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (22%) [HD]