(16 nodes) (2021) Zebrafish Models of Autosomal Dominant Ataxias. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C9orf72	C9orf72-SMCR8 complex subunit. (482 aa)
	TBX6	Uncharacterized protein. (101 aa)
	FMR1	Fragile X mental retardation 1. (627 aa)
	SASH1	Uncharacterized protein. (43 aa)
	RNF170	Ring finger protein 170. (178 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
	CRX	Homeobox domain-containing protein. (292 aa)
	CACNB4	Calcium channel, voltage-dependent, beta 4a subunit. (477 aa)
	FGFR1	Fibroblast growth factor receptor. (824 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	KCNA1	Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (492 aa)
	ATXN3	Ataxin 3. (290 aa)
	RELN	Reelin. (3462 aa)
	VLDLR	Very low density lipoprotein receptor. (885 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN3	RNF170	ENSLACP00000021644	ENSLACP00000007599	Ataxin 3.	Ring finger protein 170.	0.460
CACNB4	RNF170	ENSLACP00000014759	ENSLACP00000007599	Calcium channel, voltage-dependent, beta 4a subunit.	Ring finger protein 170.	0.501
FGFR1	SHH	ENSLACP00000015392	ENSLACP00000013019	Fibroblast growth factor receptor.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.460
FMR1	SASH1	ENSLACP00000006036	ENSLACP00000006893	Fragile X mental retardation 1.	Uncharacterized protein.	0.507
H3B8U3_LATCH	MTOR	ENSLACP00000018314	ENSLACP00000018843	Serine/threonine-protein kinase TOR.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.944
MTOR	H3B8U3_LATCH	ENSLACP00000018843	ENSLACP00000018314	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.944
RELN	VLDLR	ENSLACP00000022206	ENSLACP00000023007	Reelin.	Very low density lipoprotein receptor.	0.894
RNF170	ATXN3	ENSLACP00000007599	ENSLACP00000021644	Ring finger protein 170.	Ataxin 3.	0.460
RNF170	CACNB4	ENSLACP00000007599	ENSLACP00000014759	Ring finger protein 170.	Calcium channel, voltage-dependent, beta 4a subunit.	0.501
RNF170	SASH1	ENSLACP00000007599	ENSLACP00000006893	Ring finger protein 170.	Uncharacterized protein.	0.504
SASH1	FMR1	ENSLACP00000006893	ENSLACP00000006036	Uncharacterized protein.	Fragile X mental retardation 1.	0.507
SASH1	RNF170	ENSLACP00000006893	ENSLACP00000007599	Uncharacterized protein.	Ring finger protein 170.	0.504
SHH	FGFR1	ENSLACP00000013019	ENSLACP00000015392	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Fibroblast growth factor receptor.	0.460
VLDLR	RELN	ENSLACP00000023007	ENSLACP00000022206	Very low density lipoprotein receptor.	Reelin.	0.894