STRINGSTRING
DEPDC1 DEPDC1 LOC102345199 LOC102345199 ANGPT4 ANGPT4 TFAP2A TFAP2A IGF2 IGF2 ATM ATM EGR1 EGR1 LOC102363280 LOC102363280 PCNA PCNA IRF8 IRF8 BRCA1 BRCA1 CASP3 CASP3 HDAC4 HDAC4 PLS3 PLS3 SIRT6 SIRT6 IL6 IL6 ANGPT1 ANGPT1 LOC102348586 LOC102348586 HDAC3 HDAC3 MDM2 MDM2 SMAD3 SMAD3 BRAF BRAF BAG3 BAG3 STAT3 STAT3 FOXA1 FOXA1 MMP9 MMP9 FZD1 FZD1 PFKP PFKP CCND1 CCND1 HDAC1 HDAC1 LOC102345953 LOC102345953 DVL2 DVL2 AR AR MEST MEST H3B8U3_LATCH H3B8U3_LATCH HDAC5 HDAC5 WT1 WT1 MTOR MTOR HNRNPU HNRNPU CCND2 CCND2 AXL AXL HDAC7 HDAC7 CDK1 CDK1 LOC102347971 LOC102347971
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DEPDC1DEP domain containing 1. (823 aa)
LOC102345199Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (115 aa)
ANGPT4Angiopoietin 4. (491 aa)
TFAP2ATranscription factor AP-2 alpha. (438 aa)
IGF2Insulin like growth factor 2. (207 aa)
ATMATM serine/threonine kinase. (2375 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (505 aa)
LOC102363280Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
IRF8Interferon regulatory factor 8. (430 aa)
BRCA1BRCA1 DNA repair associated. (1873 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (290 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
PLS3Plastin 3. (630 aa)
SIRT6Sirtuin 6. (375 aa)
IL6Uncharacterized protein. (149 aa)
ANGPT1Angiopoietin 1. (499 aa)
LOC102348586Nucleolin. (705 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (485 aa)
SMAD3Mothers against decapentaplegic homolog. (358 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
BAG3BCL2 associated athanogene 3. (561 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
FOXA1Forkhead box A1. (439 aa)
MMP9Matrix metallopeptidase 9. (682 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (784 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
LOC102345953Cyclin D3; Belongs to the cyclin family. (292 aa)
DVL2Dishevelled segment polarity protein 2. (401 aa)
ARAndrogen receptor. (412 aa)
MESTMesoderm specific transcript. (338 aa)
H3B8U3_LATCHSerine/threonine-protein kinase TOR. (1418 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
WT1WT1 transcription factor. (422 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (786 aa)
CCND2Cyclin D2, b; Belongs to the cyclin family. (291 aa)
AXLAXL receptor tyrosine kinase. (872 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (873 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
LOC102347971Uncharacterized protein. (470 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.