(12 nodes) (2021) MCH-R1 Antagonist GPS18169, a Pseudopeptide, Is a Peripheral Anti-Obesity Agent in Mice. network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	GOT1	Aspartate aminotransferase. (399 aa)
	GOT2	Aspartate aminotransferase. (392 aa)
	ERAP1	Aminopeptidase. (948 aa)
	ENPEP	Aminopeptidase. (952 aa)
	LOC102347143	Uncharacterized protein. (612 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	LEPR	Leptin receptor. (1149 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	LOC102347142	Aminopeptidase. (940 aa)
	LVRN	Aminopeptidase. (977 aa)
	NPEPPS	Aminopeptidase. (879 aa)
	ANPEP	Aminopeptidase. (980 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANPEP	GOT2	ENSLACP00000020847	ENSLACP00000001398	Aminopeptidase.	Aspartate aminotransferase.	0.835
ANPEP	LOC102347143	ENSLACP00000020847	ENSLACP00000004517	Aminopeptidase.	Uncharacterized protein.	0.420
GOT1	GOT2	ENSLACP00000015852	ENSLACP00000001398	Aspartate aminotransferase.	Aspartate aminotransferase.	0.723
GOT1	H3ACE0_LATCH	ENSLACP00000015852	ENSLACP00000007311	Aspartate aminotransferase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.566
GOT1	LOC102347143	ENSLACP00000015852	ENSLACP00000004517	Aspartate aminotransferase.	Uncharacterized protein.	0.587
GOT2	ANPEP	ENSLACP00000001398	ENSLACP00000020847	Aspartate aminotransferase.	Aminopeptidase.	0.835
GOT2	GOT1	ENSLACP00000001398	ENSLACP00000015852	Aspartate aminotransferase.	Aspartate aminotransferase.	0.723
GOT2	H3ACE0_LATCH	ENSLACP00000001398	ENSLACP00000007311	Aspartate aminotransferase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.607
GOT2	LOC102347143	ENSLACP00000001398	ENSLACP00000004517	Aspartate aminotransferase.	Uncharacterized protein.	0.631
H3ACE0_LATCH	GOT1	ENSLACP00000007311	ENSLACP00000015852	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Aspartate aminotransferase.	0.566
H3ACE0_LATCH	GOT2	ENSLACP00000007311	ENSLACP00000001398	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Aspartate aminotransferase.	0.607
H3ACE0_LATCH	LEP	ENSLACP00000007311	ENSLACP00000011398	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.864
H3ACE0_LATCH	LEPR	ENSLACP00000007311	ENSLACP00000008593	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Leptin receptor.	0.660
H3ACE0_LATCH	LOC102347143	ENSLACP00000007311	ENSLACP00000004517	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.799
LEP	H3ACE0_LATCH	ENSLACP00000011398	ENSLACP00000007311	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.864
LEP	LEPR	ENSLACP00000011398	ENSLACP00000008593	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Leptin receptor.	0.936
LEPR	H3ACE0_LATCH	ENSLACP00000008593	ENSLACP00000007311	Leptin receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.660
LEPR	LEP	ENSLACP00000008593	ENSLACP00000011398	Leptin receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.936
LOC102347143	ANPEP	ENSLACP00000004517	ENSLACP00000020847	Uncharacterized protein.	Aminopeptidase.	0.420
LOC102347143	GOT1	ENSLACP00000004517	ENSLACP00000015852	Uncharacterized protein.	Aspartate aminotransferase.	0.587