STRINGSTRING
SLC1A5 SLC1A5 VEGFC VEGFC COL2A1 COL2A1 WNT10B WNT10B DVL1 DVL1 SOX9 SOX9 WNT8B WNT8B WNT2B WNT2B FZD2 FZD2 WNT5B WNT5B LOC102345634 LOC102345634 BMP7 BMP7 AXIN2 AXIN2 WNT6 WNT6 RHOA RHOA WNT10A WNT10A LOC102363206 LOC102363206 CDC42 CDC42 TCF7L2 TCF7L2 WNT4 WNT4 TCF7L2-2 TCF7L2-2 LOC102358762 LOC102358762 DVL3 DVL3 FZD6 FZD6 H3B1Q1_LATCH H3B1Q1_LATCH SLC1A4 SLC1A4 CCND1 CCND1 FZD1 FZD1 MMP13 MMP13 IGF2BP3 IGF2BP3 SLC1A6 SLC1A6 FGF3 FGF3 SLC1A2 SLC1A2 AXIN1 AXIN1 SOST SOST EZH2 EZH2 PPARG PPARG CCN4 CCN4 PANX3 PANX3 RGS18 RGS18 SLC1A1 SLC1A1 WNT3 WNT3 PORCN PORCN SRC SRC H3ACE0_LATCH H3ACE0_LATCH WNT11 WNT11 PCNA PCNA WNT7A WNT7A LOC102348363 LOC102348363 H3A6Z7_LATCH H3A6Z7_LATCH IL10 IL10 AKT1 AKT1 SLC1A7 SLC1A7 GATA3 GATA3 SLC1A3 SLC1A3 FZD4 FZD4 RYK RYK FZD8 FZD8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC1A5Amino acid transporter. (565 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (410 aa)
COL2A1Collagen type II alpha 1 chain. (1488 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
DVL1Dishevelled segment polarity protein 1. (552 aa)
SOX9SRY-box transcription factor 9. (475 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (432 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
LOC102345634Amino acid transporter. (345 aa)
BMP7Bone morphogenetic protein 7. (425 aa)
AXIN2Axin 2. (841 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
RHOAUncharacterized protein. (193 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
LOC102363206Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
CDC42Cell division cycle 42. (156 aa)
TCF7L2Transcription factor 7 like 2. (439 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
TCF7L2-2Transcription factor 7 like 2. (180 aa)
LOC102358762Amino acid transporter. (538 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
H3B1Q1_LATCHAmino acid transporter. (383 aa)
SLC1A4Amino acid transporter. (188 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
MMP13Matrix metallopeptidase 13. (467 aa)
IGF2BP3Insulin like growth factor 2 mRNA binding protein 3. (481 aa)
SLC1A6Amino acid transporter. (547 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
SLC1A2Amino acid transporter. (566 aa)
AXIN1Axin 1. (880 aa)
SOSTSclerostin. (210 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (750 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
CCN4Cellular communication network factor 4. (357 aa)
PANX3Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (390 aa)
RGS18Regulator of G protein signaling 18. (234 aa)
SLC1A1Amino acid transporter. (523 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
PORCNPorcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (463 aa)
SRCTyrosine-protein kinase. (535 aa)
H3ACE0_LATCHInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LOC102348363DAB2 interacting protein a. (1082 aa)
H3A6Z7_LATCHBardet-Biedl syndrome 1. (596 aa)
IL10Interleukin 10. (185 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (478 aa)
SLC1A7Amino acid transporter. (497 aa)
GATA3GATA binding protein 3. (447 aa)
SLC1A3Amino acid transporter. (441 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (530 aa)
RYKReceptor like tyrosine kinase. (542 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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