(21 nodes) (2021) Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	UNC93B1	Unc-93 homolog B1, TLR signaling regulator. (612 aa)
	RUNX1	Runt domain-containing protein. (191 aa)
	STAT1	Signal transducer and activator of transcription. (1179 aa)
	RUNX1-2	RUNX family transcription factor 1. (242 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (830 aa)
	CSF1R	Colony stimulating factor 1 receptor. (968 aa)
	PAX5	Paired box 5. (189 aa)
	MMP13	Matrix metallopeptidase 13. (467 aa)
	MMP9	Matrix metallopeptidase 9. (682 aa)
	MPP3	Membrane palmitoylated protein 3; Belongs to the MAGUK family. (586 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	TET2	Tet_JBP domain-containing protein. (2001 aa)
	IL17F	Interleukin 17F. (166 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	IFNAR1	Uncharacterized protein. (548 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	IRF2	Interferon regulatory factor. (342 aa)
	IL1RL1	Uncharacterized protein. (184 aa)
	IRF8	Interferon regulatory factor 8. (430 aa)
	IL6R	Interleukin 6 receptor. (469 aa)
	TLR9	Toll-like receptor 9. (1039 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSF1R	STAT1	ENSLACP00000016266	ENSLACP00000007692	Colony stimulating factor 1 receptor.	Signal transducer and activator of transcription.	0.456
CSF1R	TLR3	ENSLACP00000016266	ENSLACP00000012956	Colony stimulating factor 1 receptor.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.450
IFNAR1	IRF2	ENSLACP00000002973	ENSLACP00000004510	Uncharacterized protein.	Interferon regulatory factor.	0.421
IFNAR1	MYD88	ENSLACP00000002973	ENSLACP00000019094	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.479
IFNAR1	STAT1	ENSLACP00000002973	ENSLACP00000007692	Uncharacterized protein.	Signal transducer and activator of transcription.	0.924
IFNAR1	TLR3	ENSLACP00000002973	ENSLACP00000012956	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.582
IL1RL1	MYD88	ENSLACP00000006256	ENSLACP00000019094	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.808
IL1RL1	TRAF6	ENSLACP00000006256	ENSLACP00000003556	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.752
IL6R	STAT1	ENSLACP00000022612	ENSLACP00000007692	Interleukin 6 receptor.	Signal transducer and activator of transcription.	0.559
IRF2	IFNAR1	ENSLACP00000004510	ENSLACP00000002973	Interferon regulatory factor.	Uncharacterized protein.	0.421
IRF2	MYD88	ENSLACP00000004510	ENSLACP00000019094	Interferon regulatory factor.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.625
IRF2	STAT1	ENSLACP00000004510	ENSLACP00000007692	Interferon regulatory factor.	Signal transducer and activator of transcription.	0.438
IRF2	TRAF6	ENSLACP00000004510	ENSLACP00000003556	Interferon regulatory factor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.402
IRF8	MMP9	ENSLACP00000006607	ENSLACP00000014693	Interferon regulatory factor 8.	Matrix metallopeptidase 9.	0.432
IRF8	MYD88	ENSLACP00000006607	ENSLACP00000019094	Interferon regulatory factor 8.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.640
IRF8	TLR3	ENSLACP00000006607	ENSLACP00000012956	Interferon regulatory factor 8.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.435
IRF8	TRAF6	ENSLACP00000006607	ENSLACP00000003556	Interferon regulatory factor 8.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.669
MMP13	MMP9	ENSLACP00000014803	ENSLACP00000014693	Matrix metallopeptidase 13.	Matrix metallopeptidase 9.	0.676
MMP9	IRF8	ENSLACP00000014693	ENSLACP00000006607	Matrix metallopeptidase 9.	Interferon regulatory factor 8.	0.432
MMP9	MMP13	ENSLACP00000014693	ENSLACP00000014803	Matrix metallopeptidase 9.	Matrix metallopeptidase 13.	0.676