STRINGSTRING
NOTCH3 NOTCH3 LOC102353790 LOC102353790 CRYGS CRYGS PTEN PTEN BFSP2 BFSP2 FOXO1 FOXO1 CRYBA1 CRYBA1 BFSP1 BFSP1 XIAP XIAP HIPK3 HIPK3 HSPB2 HSPB2 CRYAB CRYAB AKT2 AKT2 NOTCH2 NOTCH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH3Notch receptor 3. (1577 aa)
LOC102353790Uncharacterized protein. (899 aa)
CRYGSCrystallin gamma S; Belongs to the beta/gamma-crystallin family. (178 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
BFSP2Beaded filament structural protein 2; Belongs to the intermediate filament family. (422 aa)
FOXO1Forkhead box O1. (633 aa)
CRYBA1Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (199 aa)
BFSP1Beaded filament structural protein 1; Belongs to the intermediate filament family. (652 aa)
XIAPX-linked inhibitor of apoptosis. (606 aa)
HIPK3Homeodomain interacting protein kinase 3. (1204 aa)
HSPB2Heat shock protein, alpha-crystallin-related, b2; Belongs to the small heat shock protein (HSP20) family. (180 aa)
CRYABCrystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (173 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (488 aa)
NOTCH2Notch receptor 2. (2489 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.