STRINGSTRING
FGF5 FGF5 FGFR3 FGFR3 GRB2 GRB2 CCNA2 CCNA2 JAG1 JAG1 DUSP6 DUSP6 KL KL H3A2B0_LATCH H3A2B0_LATCH SNAI2 SNAI2 LOC102356182 LOC102356182 SOX2 SOX2 FGFR2 FGFR2 STAT1 STAT1 FGF8 FGF8 FGF11 FGF11 IL6 IL6 GAB1 GAB1 ANGPT2 ANGPT2 SYT1 SYT1 FGF16 FGF16 FGF22 FGF22 FGF13 FGF13 KDM5B KDM5B FGF3 FGF3 FGF4 FGF4 GLB1L GLB1L FGF19 FGF19 MMP9 MMP9 FGF20 FGF20 CRKL CRKL MMP2 MMP2 FGF1 FGF1 FGFR1 FGFR1 FGF18 FGF18 ADAMTS8 ADAMTS8 FGF7 FGF7 SPRY1 SPRY1 SPHK1 SPHK1 H3B8U3_LATCH H3B8U3_LATCH LOC102350793 LOC102350793 FGF14 FGF14 MTOR MTOR FGF2 FGF2 FGF12 FGF12 BMP7 BMP7 H3BES6_LATCH H3BES6_LATCH FGF6 FGF6 H3BGQ4_LATCH H3BGQ4_LATCH GLB1L2 GLB1L2 CTSK CTSK IGF1 IGF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FGFR3Fibroblast growth factor receptor. (778 aa)
GRB2Growth factor receptor bound protein 2. (292 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (447 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
KLKlotho. (1004 aa)
H3A2B0_LATCHFibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
SNAI2Snail family zinc finger 2. (268 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
SOX2SRY-box transcription factor 2. (315 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
STAT1Signal transducer and activator of transcription. (1179 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
IL6Uncharacterized protein. (149 aa)
GAB1GRB2 associated binding protein 1. (534 aa)
ANGPT2Angiopoietin 2. (493 aa)
SYT1Synaptotagmin 1. (384 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
KDM5BLysine demethylase 5B. (1659 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
GLB1LGalactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. (636 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
MMP9Matrix metallopeptidase 9. (682 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CRKLCRK like proto-oncogene, adaptor protein. (219 aa)
MMP2Matrix metallopeptidase 2. (653 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGFR1Fibroblast growth factor receptor. (824 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif 8. (949 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
SPHK1Sphingosine kinase 1. (508 aa)
H3B8U3_LATCHSerine/threonine-protein kinase TOR. (1418 aa)
LOC102350793Beta-galactosidase. (627 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (163 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
BMP7Bone morphogenetic protein 7. (425 aa)
H3BES6_LATCHAngiopoietin 2b. (498 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
H3BGQ4_LATCHC2 domain-containing protein. (310 aa)
GLB1L2Beta-galactosidase. (639 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (333 aa)
IGF1Insulin like growth factor 1. (136 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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