(19 nodes) (2021) Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	H3F3B	Histone H3; Belongs to the histone H3 family. (136 aa)
	PTCH1	Patched 1. (1287 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (210 aa)
	SCG5	Secretogranin V. (207 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	H3AFX1_LATCH	Rho GTPase activating protein 11A. (1011 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	LOC102355712	Histone H3; Belongs to the histone H3 family. (129 aa)
	CTCF	CCCTC-binding factor. (773 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
	H3B1U0_LATCH	Uncharacterized protein. (549 aa)
	H3F3B-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	RPL19	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (196 aa)
	PAX9	Paired box 9. (342 aa)
	HOXA13	Homeobox A13b. (295 aa)
	ALX4	ALX homeobox 4. (369 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX4	GLI3	ENSLACP00000020003	ENSLACP00000004224	ALX homeobox 4.	GLI family zinc finger 3.	0.531
ALX4	HAND2	ENSLACP00000020003	ENSLACP00000004871	ALX homeobox 4.	Heart and neural crest derivatives expressed 2.	0.526
ALX4	PAX9	ENSLACP00000020003	ENSLACP00000018070	ALX homeobox 4.	Paired box 9.	0.444
BMP4	FGF8	ENSLACP00000021723	ENSLACP00000007843	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.642
BMP4	GLI3	ENSLACP00000021723	ENSLACP00000004224	Bone morphogenetic protein 4.	GLI family zinc finger 3.	0.444
BMP4	HAND2	ENSLACP00000021723	ENSLACP00000004871	Bone morphogenetic protein 4.	Heart and neural crest derivatives expressed 2.	0.543
BMP4	IHH	ENSLACP00000021723	ENSLACP00000004851	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.543
BMP4	PAX9	ENSLACP00000021723	ENSLACP00000018070	Bone morphogenetic protein 4.	Paired box 9.	0.482
BMP4	PTCH1	ENSLACP00000021723	ENSLACP00000004070	Bone morphogenetic protein 4.	Patched 1.	0.605
BMP4	SHH	ENSLACP00000021723	ENSLACP00000013019	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.760
BMP4	SMAD4	ENSLACP00000021723	ENSLACP00000009312	Bone morphogenetic protein 4.	MH2 domain-containing protein.	0.815
CTCF	H3AFX1_LATCH	ENSLACP00000011174	ENSLACP00000008542	CCCTC-binding factor.	Rho GTPase activating protein 11A.	0.408
CTCF	H3F3B	ENSLACP00000011174	ENSLACP00000001165	CCCTC-binding factor.	Histone H3; Belongs to the histone H3 family.	0.484
CTCF	H3F3B-2	ENSLACP00000011174	ENSLACP00000015909	CCCTC-binding factor.	Histone H3; Belongs to the histone H3 family.	0.485
CTCF	LOC102355712	ENSLACP00000011174	ENSLACP00000009501	CCCTC-binding factor.	Histone H3; Belongs to the histone H3 family.	0.486
FGF8	BMP4	ENSLACP00000007843	ENSLACP00000021723	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.642
FGF8	GLI3	ENSLACP00000007843	ENSLACP00000004224	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GLI family zinc finger 3.	0.634
FGF8	HAND2	ENSLACP00000007843	ENSLACP00000004871	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heart and neural crest derivatives expressed 2.	0.606
FGF8	HOXA13	ENSLACP00000007843	ENSLACP00000019815	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox A13b.	0.449
FGF8	IHH	ENSLACP00000007843	ENSLACP00000004851	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.745