(30 nodes) (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHRD	Chordin; Belongs to the chordin family. (948 aa)
	DLX1	Distal-less homeobox 1. (253 aa)
	FOXK1	Forkhead box K1. (673 aa)
	PITX1	Homeobox protein. (305 aa)
	SOX10	SRY-box transcription factor 10. (451 aa)
	PRDM14	PR/SET domain 14. (599 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (273 aa)
	MEIS1	Meis homeobox 1. (466 aa)
	SOX2	SRY-box transcription factor 2. (315 aa)
	SOX3	SRY-box transcription factor 3. (304 aa)
	ZIC4	Zic family member 4. (525 aa)
	MMUT	Methylmalonyl-CoA mutase. (754 aa)
	TGIF1	TGFB induced factor homeobox 1. (272 aa)
	FOXP4	Forkhead box P4. (465 aa)
	FOXO1	Forkhead box O1. (633 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (359 aa)
	TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor. (327 aa)
	LOC102362664	POU domain protein. (452 aa)
	PXDN	Peroxidasin. (1149 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
	PAX6	Paired box 6. (463 aa)
	FOXD3	Forkhead box D3. (373 aa)
	EBF1	Uncharacterized protein. (161 aa)
	HOXA10	Homeobox A10. (557 aa)
	SNAI1	Snail family transcriptional repressor 1. (257 aa)
	PXDNL	Peroxidasin like. (1276 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	PRDM11	SET domain-containing protein. (446 aa)
	ESRRA	Estrogen-related receptor gamma b. (416 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CHRD	ENSLACP00000021723	ENSLACP00000000821	Bone morphogenetic protein 4.	Chordin; Belongs to the chordin family.	0.977
BMP4	DLX1	ENSLACP00000021723	ENSLACP00000002197	Bone morphogenetic protein 4.	Distal-less homeobox 1.	0.404
BMP4	HOXA10	ENSLACP00000021723	ENSLACP00000019765	Bone morphogenetic protein 4.	Homeobox A10.	0.420
BMP4	PAX6	ENSLACP00000021723	ENSLACP00000017411	Bone morphogenetic protein 4.	Paired box 6.	0.404
BMP4	PITX1	ENSLACP00000021723	ENSLACP00000003851	Bone morphogenetic protein 4.	Homeobox protein.	0.444
BMP4	SOX2	ENSLACP00000021723	ENSLACP00000007400	Bone morphogenetic protein 4.	SRY-box transcription factor 2.	0.477
CHRD	BMP4	ENSLACP00000000821	ENSLACP00000021723	Chordin; Belongs to the chordin family.	Bone morphogenetic protein 4.	0.977
CHRD	SNAI1	ENSLACP00000000821	ENSLACP00000020148	Chordin; Belongs to the chordin family.	Snail family transcriptional repressor 1.	0.489
DLX1	BMP4	ENSLACP00000002197	ENSLACP00000021723	Distal-less homeobox 1.	Bone morphogenetic protein 4.	0.404
DLX1	MEIS1	ENSLACP00000002197	ENSLACP00000006547	Distal-less homeobox 1.	Meis homeobox 1.	0.491
ESRRA	PRDM14	ENSLACP00000020345	ENSLACP00000005725	Estrogen-related receptor gamma b.	PR/SET domain 14.	0.448
FOXD3	SOX10	ENSLACP00000017581	ENSLACP00000004990	Forkhead box D3.	SRY-box transcription factor 10.	0.695
FOXP4	LOC102362664	ENSLACP00000011525	ENSLACP00000014097	Forkhead box P4.	POU domain protein.	0.450
FOXP4	PRDM14	ENSLACP00000011525	ENSLACP00000005725	Forkhead box P4.	PR/SET domain 14.	0.494
GAPDH	MMUT	ENSLACP00000012705	ENSLACP00000010384	Glyceraldehyde-3-phosphate dehydrogenase.	Methylmalonyl-CoA mutase.	0.473
GAPDH	PXDN	ENSLACP00000012705	ENSLACP00000014158	Glyceraldehyde-3-phosphate dehydrogenase.	Peroxidasin.	0.610
GAPDH	PXDNL	ENSLACP00000012705	ENSLACP00000022207	Glyceraldehyde-3-phosphate dehydrogenase.	Peroxidasin like.	0.611
HDAC1	SNAI1	ENSLACP00000015194	ENSLACP00000020148	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Snail family transcriptional repressor 1.	0.411
HDAC1	SOX10	ENSLACP00000015194	ENSLACP00000004990	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	SRY-box transcription factor 10.	0.408
HDAC1	TGIF1	ENSLACP00000015194	ENSLACP00000011257	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	TGFB induced factor homeobox 1.	0.571