STRINGSTRING
SMAD2 SMAD2 ADIPOQ ADIPOQ H2ZUZ3_LATCH H2ZUZ3_LATCH CAMK4 CAMK4 H2ZZF1_LATCH H2ZZF1_LATCH AHR AHR MAP2K4 MAP2K4 HMOX1 HMOX1 IL18 IL18 H3BH94_LATCH H3BH94_LATCH CASP9 CASP9 TGFB1 TGFB1 HES4 HES4 NOS2 NOS2 LOC102348047 LOC102348047 LOC102352268 LOC102352268 LOC102347787 LOC102347787 GPX3 GPX3 GPX1 GPX1 LOC102346019 LOC102346019 MYD88 MYD88 TGFB3 TGFB3 MTOR MTOR EDN1 EDN1 SOD2 SOD2 VCAM1 VCAM1 MAP1B MAP1B LOC102365332 LOC102365332 CSF1R CSF1R LOC102363742 LOC102363742 TRAF1 TRAF1 H3B037_LATCH H3B037_LATCH CCND1 CCND1 TRPA1 TRPA1 GPX8 GPX8 CAV1 CAV1 ANK1 ANK1 STAT3 STAT3 SMAD3 SMAD3 GPX7 GPX7 LEP LEP HES1 HES1 PPARG PPARG NFE2L2 NFE2L2 IL6 IL6 NQO1 NQO1 SIRT1 SIRT1 SIRT6 SIRT6 CCNB1 CCNB1 TGFB2 TGFB2 HMGB1 HMGB1 CASP3 CASP3 RARB RARB JAK2 JAK2 SIRT3 SIRT3 CHRNA7 CHRNA7 IL10 IL10 CD40 CD40
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (259 aa)
H2ZUZ3_LATCHUncharacterized protein. (515 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (373 aa)
H2ZZF1_LATCHPAS domain-containing protein. (1038 aa)
AHRAryl hydrocarbon receptor 1a. (868 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (463 aa)
HMOX1Heme oxygenase 1. (300 aa)
IL18Uncharacterized protein. (200 aa)
H3BH94_LATCHPAS domain-containing protein. (733 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (457 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
HES4Hes family bHLH transcription factor 4. (296 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
LOC102348047Sushi domain-containing protein. (802 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
LOC102347787Sushi domain-containing protein. (742 aa)
GPX3Glutathione peroxidase 3. (108 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
LOC102346019C1q domain-containing protein. (226 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
EDN1Endothelin 1. (216 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (223 aa)
VCAM1Vascular cell adhesion molecule 1. (733 aa)
MAP1BMicrotubule associated protein 1B. (2174 aa)
LOC102365332Apolipoprotein Ea. (278 aa)
CSF1RColony stimulating factor 1 receptor. (968 aa)
LOC102363742Uncharacterized protein; Belongs to the peptidase C14A family. (394 aa)
TRAF1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (565 aa)
H3B037_LATCHGlutathione peroxidase; Belongs to the glutathione peroxidase family. (112 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1138 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (173 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
ANK1Ankyrin 1. (1879 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
SMAD3Mothers against decapentaplegic homolog. (358 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (185 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
HES1Hes family bHLH transcription factor 1. (269 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (590 aa)
IL6Uncharacterized protein. (149 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (254 aa)
SIRT1Sirtuin 1. (729 aa)
SIRT6Sirtuin 6. (375 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (404 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
HMGB1High mobility group box 1. (216 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (290 aa)
RARBNR LBD domain-containing protein. (299 aa)
JAK2Tyrosine-protein kinase. (1152 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
CHRNA7Cholinergic receptor, nicotinic, alpha 7 (neuronal). (506 aa)
IL10Interleukin 10. (185 aa)
CD40TNFR-Cys domain-containing protein. (167 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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