(13 nodes) (2021) Retinaldehyde Dehydrogenase Inhibition-Related Adverse Outcome Pathway: Potential Risk of Retinoic Acid Synthesis Inhibition during Embryogenesis. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXA3	Homeobox A3. (411 aa)
	CRABP2	Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
	RARS1	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (660 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (552 aa)
	HOXB1	Homeobox B1. (309 aa)
	CDX1	Caudal type homeobox 1a. (259 aa)
	PAX6	Paired box 6. (463 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	PITX2	Homeobox protein. (314 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (273 aa)
	HOXD4	Homeobox D4a. (251 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	HOXA5	Homeobox A5. (269 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF8	PAX6	ENSLACP00000007843	ENSLACP00000017411	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Paired box 6.	0.691
FGF8	PITX2	ENSLACP00000007843	ENSLACP00000006331	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein.	0.537
FGF8	RARS1	ENSLACP00000007843	ENSLACP00000018021	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.402
HOXA3	HOXA5	ENSLACP00000019613	ENSLACP00000019710	Homeobox A3.	Homeobox A5.	0.765
HOXA5	HOXA3	ENSLACP00000019710	ENSLACP00000019613	Homeobox A5.	Homeobox A3.	0.765
OLIG2	PAX6	ENSLACP00000006181	ENSLACP00000017411	Oligodendrocyte transcription factor 2.	Paired box 6.	0.669
PAX6	FGF8	ENSLACP00000017411	ENSLACP00000007843	Paired box 6.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.691
PAX6	OLIG2	ENSLACP00000017411	ENSLACP00000006181	Paired box 6.	Oligodendrocyte transcription factor 2.	0.669
PITX2	FGF8	ENSLACP00000006331	ENSLACP00000007843	Homeobox protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.537
RARS1	FGF8	ENSLACP00000018021	ENSLACP00000007843	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.402