(40 nodes) (2022) The Influence of Temperature on the Antiviral Response of mIgM(+) B Lymphocytes Against Hirame Novirhabdovirus in Flounder (Paralichthys olivaceus). network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	RAC1	Rac family small GTPase 1. (192 aa)
	VCL	Vinculin. (832 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (822 aa)
	LOC102360381	Uncharacterized protein. (300 aa)
	LOC102349081	Integrin beta; Belongs to the integrin beta chain family. (570 aa)
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	LOC102347143	Uncharacterized protein. (612 aa)
	CLDN10	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (232 aa)
	PLA2G4A	Phospholipase A2. (750 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (403 aa)
	PTPN11	Protein tyrosine phosphatase non-receptor type 11. (586 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (290 aa)
	PAK1	Non-specific serine/threonine protein kinase. (545 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (205 aa)
	PLD1	Phospholipase. (1072 aa)
	DDX10	DEAD-box helicase 10; Belongs to the DEAD box helicase family. (575 aa)
	TLN1	Talin 1. (2546 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (673 aa)
	DHX58	DExH-box helicase 58. (680 aa)
	CANX	Calnexin. (625 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	LOC102361670	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (376 aa)
	LOC102357450	Uncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
	PAX5	Paired box 5. (189 aa)
	AFDN	Afadin, adherens junction formation factor. (1854 aa)
	RUNX3	RUNX family transcription factor 3. (179 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (381 aa)
	TBXA2R	Thromboxane A2 receptor. (351 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (340 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1462 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (657 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	CALR3	Calreticulin. (416 aa)
	TLR9	Toll-like receptor 9. (1039 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1219 aa)
	GP1BB	Glycoprotein Ib platelet subunit beta. (204 aa)
	LOC102352006	Uncharacterized protein. (163 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFDN	LOC102352006	ENSLACP00000015429	ENSLACP00000023412	Afadin, adherens junction formation factor.	Uncharacterized protein.	0.505
AFDN	RAC1	ENSLACP00000015429	ENSLACP00000015032	Afadin, adherens junction formation factor.	Rac family small GTPase 1.	0.433
AFDN	ROCK2	ENSLACP00000015429	ENSLACP00000017818	Afadin, adherens junction formation factor.	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.419
AFDN	VCL	ENSLACP00000015429	ENSLACP00000000289	Afadin, adherens junction formation factor.	Vinculin.	0.777
CALR3	CANX	ENSLACP00000020782	ENSLACP00000012732	Calreticulin.	Calnexin.	0.880
CALR3	LOC102357450	ENSLACP00000020782	ENSLACP00000014115	Calreticulin.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.516
CANX	CALR3	ENSLACP00000012732	ENSLACP00000020782	Calnexin.	Calreticulin.	0.880
CANX	DNM2	ENSLACP00000012732	ENSLACP00000018566	Calnexin.	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.454
CANX	LOC102357450	ENSLACP00000012732	ENSLACP00000014115	Calnexin.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.492
CANX	LOC102360381	ENSLACP00000012732	ENSLACP00000001920	Calnexin.	Uncharacterized protein.	0.881
CASP3	LOC102347143	ENSLACP00000007386	ENSLACP00000004517	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.494
CASP3	LOC102357450	ENSLACP00000007386	ENSLACP00000014115	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.423
CASP3	PAK1	ENSLACP00000007386	ENSLACP00000008886	Caspase 3; Belongs to the peptidase C14A family.	Non-specific serine/threonine protein kinase.	0.909
CASP3	PTK2	ENSLACP00000007386	ENSLACP00000012721	Caspase 3; Belongs to the peptidase C14A family.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.575
CASP3	ROCK2	ENSLACP00000007386	ENSLACP00000017818	Caspase 3; Belongs to the peptidase C14A family.	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.515
CD40	TLR3	ENSLACP00000004148	ENSLACP00000012956	TNFR-Cys domain-containing protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.503
CD40	TLR9	ENSLACP00000004148	ENSLACP00000020965	TNFR-Cys domain-containing protein.	Toll-like receptor 9.	0.488
CLDN10	DNM2	ENSLACP00000005269	ENSLACP00000018566	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.671
CLDN10	ITPR3	ENSLACP00000005269	ENSLACP00000018403	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Inositol 1,4,5-trisphosphate receptor type 3.	0.410
DDX10	DHX58	ENSLACP00000010760	ENSLACP00000012725	DEAD-box helicase 10; Belongs to the DEAD box helicase family.	DExH-box helicase 58.	0.585