(14 nodes) (2022) Comparative transcriptome analysis reveals immunoregulation mechanism of lncRNA-mRNA in gill and skin of large yellow croaker (Larimichthys crocea) in response to Cryptocaryon irritans infection. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLEK	Pleckstrin. (353 aa)
	TNFAIP3	TNF alpha induced protein 3. (785 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (620 aa)
	TMEM181	Transmembrane protein 181. (525 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (505 aa)
	CEBPB	CCAAT/enhancer-binding protein. (291 aa)
	LOC102365561	C3H1-type domain-containing protein. (322 aa)
	C3	Uncharacterized protein. (1286 aa)
	LOC102366872	TIR domain-containing protein; Belongs to the Toll-like receptor family. (862 aa)
	CNTF	Uncharacterized protein. (206 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (298 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEBPB	NFKBIA	ENSLACP00000002325	ENSLACP00000020134	CCAAT/enhancer-binding protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.553
CNTF	TNFAIP3	ENSLACP00000022760	ENSLACP00000016527	Uncharacterized protein.	TNF alpha induced protein 3.	0.504
LOC102365561	NFKBIA	ENSLACP00000000036	ENSLACP00000020134	C3H1-type domain-containing protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.505
LOC102365561	PTGS2	ENSLACP00000000036	ENSLACP00000009260	C3H1-type domain-containing protein.	Prostaglandin-endoperoxide synthase 2.	0.470
LOC102365561	TMEM181	ENSLACP00000000036	ENSLACP00000008852	C3H1-type domain-containing protein.	Transmembrane protein 181.	0.745
LOC102365561	TNFAIP3	ENSLACP00000000036	ENSLACP00000016527	C3H1-type domain-containing protein.	TNF alpha induced protein 3.	0.652
LOC102366872	MYD88	ENSLACP00000017461	ENSLACP00000019094	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.985
LOC102366872	TNFAIP3	ENSLACP00000017461	ENSLACP00000016527	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TNF alpha induced protein 3.	0.404
MYD88	LOC102366872	ENSLACP00000019094	ENSLACP00000017461	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.985
MYD88	NFKBIA	ENSLACP00000019094	ENSLACP00000020134	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.641
MYD88	PTGS2	ENSLACP00000019094	ENSLACP00000009260	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Prostaglandin-endoperoxide synthase 2.	0.427
NFKBIA	CEBPB	ENSLACP00000020134	ENSLACP00000002325	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	CCAAT/enhancer-binding protein.	0.553
NFKBIA	LOC102365561	ENSLACP00000020134	ENSLACP00000000036	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	C3H1-type domain-containing protein.	0.505
NFKBIA	MYD88	ENSLACP00000020134	ENSLACP00000019094	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.641
NFKBIA	PTGS2	ENSLACP00000020134	ENSLACP00000009260	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	Prostaglandin-endoperoxide synthase 2.	0.548
NFKBIA	TMEM181	ENSLACP00000020134	ENSLACP00000008852	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	Transmembrane protein 181.	0.516
NFKBIA	TNFAIP3	ENSLACP00000020134	ENSLACP00000016527	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	TNF alpha induced protein 3.	0.736
PTGS2	LOC102365561	ENSLACP00000009260	ENSLACP00000000036	Prostaglandin-endoperoxide synthase 2.	C3H1-type domain-containing protein.	0.470
PTGS2	MYD88	ENSLACP00000009260	ENSLACP00000019094	Prostaglandin-endoperoxide synthase 2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.427
PTGS2	NFKBIA	ENSLACP00000009260	ENSLACP00000020134	Prostaglandin-endoperoxide synthase 2.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.548