(33 nodes) (2022) Rewiring the Metabolic Network to Increase Docosahexaenoic Acid Productivity in Crypthecodinium cohnii by Fermentation Supernatant-Based Adaptive Laboratory Evolution. network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	ATP5F1B	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (312 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (702 aa)
	H3AIU3_LATCH	Dihydrolipoamide dehydrogenase. (233 aa)
	SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (670 aa)
	OLAH	Oleoyl-ACP hydrolase. (253 aa)
	LOC102350238	Acyl-CoA synthetase bubblegum family member 1. (537 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (539 aa)
	ACSL6	Uncharacterized protein. (749 aa)
	LOC102349700	Acyl-CoA synthetase bubblegum family member 1. (688 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (800 aa)
	ACSL3	Acyl-CoA synthetase long chain family member 3. (711 aa)
	ATP6V1B1	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (392 aa)
	SUCLG1	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (335 aa)
	ACSL4	Acyl-CoA synthetase long chain family member 4. (713 aa)
	ATP6V1F	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (121 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (422 aa)
	DLD	Dihydrolipoamide dehydrogenase. (236 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (555 aa)
	ATP5F1A	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (530 aa)
	ALDOB	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	CS	Citrate synthase; Belongs to the citrate synthase family. (468 aa)
	CYC1	Cytochrome c1. (304 aa)
	WT1	WT1 transcription factor. (422 aa)
	SDHB	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (285 aa)
	ACAA1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
	H3B262_LATCH	AMP-binding domain-containing protein. (674 aa)
	PGK1	Phosphoglycerate kinase. (389 aa)
	LNX1	Ligand of numb-protein X 1. (732 aa)
	LOC102364477	AMP-binding domain-containing protein. (704 aa)
	ACSL5	Acyl-CoA synthetase long chain family member 5. (683 aa)
	ALDOA	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	ALDOC	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (340 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACAT1	ENSLACP00000018116	ENSLACP00000002727	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.930
ACAA1	ACSL1	ENSLACP00000018116	ENSLACP00000009815	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase long chain family member 1.	0.659
ACAA1	ACSL3	ENSLACP00000018116	ENSLACP00000004477	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase long chain family member 3.	0.662
ACAA1	ACSL4	ENSLACP00000018116	ENSLACP00000003329	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase long chain family member 4.	0.642
ACAA1	ACSL5	ENSLACP00000018116	ENSLACP00000012317	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase long chain family member 5.	0.653
ACAA1	ACSL6	ENSLACP00000018116	ENSLACP00000006581	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.673
ACAA1	ALDOB	ENSLACP00000018116	ENSLACP00000022754	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.415
ACAA1	ALDOC	ENSLACP00000018116	ENSLACP00000010076	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.454
ACAA1	ATP5F1A	ENSLACP00000018116	ENSLACP00000000021	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.465
ACAA1	ATP5F1B	ENSLACP00000018116	ENSLACP00000010603	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.456
ACAA1	ATP6V1B1	ENSLACP00000018116	ENSLACP00000004376	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.481
ACAA1	ATP6V1F	ENSLACP00000018116	ENSLACP00000003251	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.566
ACAA1	CS	ENSLACP00000018116	ENSLACP00000021587	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Citrate synthase; Belongs to the citrate synthase family.	0.955
ACAA1	CYC1	ENSLACP00000018116	ENSLACP00000021509	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Cytochrome c1.	0.434
ACAA1	DLD	ENSLACP00000018116	ENSLACP00000002388	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Dihydrolipoamide dehydrogenase.	0.575
ACAA1	GPI	ENSLACP00000018116	ENSLACP00000000902	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.601
ACAA1	H3AIU3_LATCH	ENSLACP00000018116	ENSLACP00000009564	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Dihydrolipoamide dehydrogenase.	0.575
ACAA1	H3B262_LATCH	ENSLACP00000018116	ENSLACP00000015983	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	AMP-binding domain-containing protein.	0.732
ACAA1	LOC102349700	ENSLACP00000018116	ENSLACP00000006392	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase bubblegum family member 1.	0.731
ACAA1	LOC102350238	ENSLACP00000018116	ENSLACP00000007337	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase bubblegum family member 1.	0.731