STRINGSTRING
PALB2 PALB2 NF1 NF1 CACNA1C CACNA1C MSH6 MSH6 LDLR LDLR TTN TTN TP53 TP53 TNXB TNXB LMNA LMNA MYH7 MYH7 H2ZX83_LATCH H2ZX83_LATCH MECP2 MECP2 ADGRV1 ADGRV1 MLH1 MLH1 MAF MAF BRCA1 BRCA1 ATM ATM DNAH5 DNAH5 DNAH11 DNAH11 FBN2 FBN2 GRIN2A GRIN2A LOC102360187 LOC102360187
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PALB2PALB2_WD40 domain-containing protein. (874 aa)
NF1Neurofibromin 1. (2814 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2064 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
LDLRLow density lipoprotein receptor. (851 aa)
TTNTitin, tandem duplicate 2. (21846 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
TNXBUncharacterized protein. (1830 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (678 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1936 aa)
H2ZX83_LATCHMutS homolog 2 (E. coli). (360 aa)
MECP2Methyl-CpG binding protein 2. (459 aa)
ADGRV1Adhesion G protein-coupled receptor V1. (5847 aa)
MLH1MutL homolog 1. (821 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (329 aa)
BRCA1BRCA1 DNA repair associated. (1873 aa)
ATMATM serine/threonine kinase. (2375 aa)
DNAH5Dynein axonemal heavy chain 5. (4680 aa)
DNAH11Dynein axonemal heavy chain 11. (3578 aa)
FBN2Uncharacterized protein. (2561 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1088 aa)
LOC102360187MutS homolog 2 (E. coli). (447 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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