STRINGSTRING
OLIG2 OLIG2 H2ZZF1_LATCH H2ZZF1_LATCH AHR AHR GATA3 GATA3 NOTCH3 NOTCH3 H3A2B0_LATCH H3A2B0_LATCH LOC102356182 LOC102356182 IRF8 IRF8 HBEGF HBEGF H3ACE0_LATCH H3ACE0_LATCH H3ACJ0_LATCH H3ACJ0_LATCH SOX2 SOX2 LOC102362951 LOC102362951 NTF3 NTF3 FGF8 FGF8 EP300 EP300 AQP4 AQP4 HDAC4 HDAC4 FGF11 FGF11 HDAC3 HDAC3 FGF16 FGF16 FGF22 FGF22 BDNF BDNF SHH SHH FGF13 FGF13 STAT3 STAT3 FGF3 FGF3 SPRY4 SPRY4 FGF4 FGF4 PRKACB PRKACB FGF19 FGF19 FGF20 FGF20 FGF1 FGF1 HDAC1 HDAC1 FGF18 FGF18 FGF7 FGF7 PTCH2 PTCH2 FGF5 FGF5 APOBEC2 APOBEC2 HDAC5 HDAC5 FGF14 FGF14 FGF2 FGF2 FGF12 FGF12 ATOH7 ATOH7 FGF6 FGF6 H3BH94_LATCH H3BH94_LATCH MDK MDK HDAC7 HDAC7 NOTCH2 NOTCH2 IGF1 IGF1 LOC102353790 LOC102353790 CCN2 CCN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OLIG2Oligodendrocyte transcription factor 2. (273 aa)
H2ZZF1_LATCHPAS domain-containing protein. (1038 aa)
AHRAryl hydrocarbon receptor 1a. (868 aa)
GATA3GATA binding protein 3. (447 aa)
NOTCH3Notch receptor 3. (1577 aa)
H3A2B0_LATCHFibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
IRF8Interferon regulatory factor 8. (430 aa)
HBEGFHeparin binding EGF like growth factor. (209 aa)
H3ACE0_LATCHInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
H3ACJ0_LATCHCellular communication network factor 2b. (348 aa)
SOX2SRY-box transcription factor 2. (315 aa)
LOC102362951Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (255 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
EP300E1A binding protein p300. (1119 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (319 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
BDNFBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (254 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
SPRY4Sprouty RTK signaling antagonist 4. (282 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
PRKACBUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PTCH2Patched 2. (1134 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
APOBEC2Apolipoprotein B mRNA editing enzyme catalytic subunit 2. (230 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (163 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
ATOH7Atonal bHLH transcription factor 7. (151 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
H3BH94_LATCHPAS domain-containing protein. (733 aa)
MDKMidkine. (141 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (873 aa)
NOTCH2Notch receptor 2. (2489 aa)
IGF1Insulin like growth factor 1. (136 aa)
LOC102353790Uncharacterized protein. (899 aa)
CCN2Cellular communication network factor 2. (344 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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