(16 nodes) (2022) An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates. network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	LOC102347143	Uncharacterized protein. (612 aa)
	LOC102358266	Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	MDK	Midkine. (141 aa)
	AXIN2	Axin 2. (841 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	ISL1	ISL LIM homeobox 1. (356 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
	SMAD3	Mothers against decapentaplegic homolog. (358 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (290 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	SMAD7	Mothers against decapentaplegic homolog. (377 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	IHH	ENSLACP00000019725	ENSLACP00000004851	Axin 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.418
AXIN2	LEF1	ENSLACP00000019725	ENSLACP00000005598	Axin 2.	Lymphoid enhancer binding factor 1.	0.762
AXIN2	LOC102358266	ENSLACP00000019725	ENSLACP00000005525	Axin 2.	Dickkopf WNT signaling pathway inhibitor 1b.	0.623
AXIN2	SHH	ENSLACP00000019725	ENSLACP00000013019	Axin 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.419
BAMBI	SMAD3	ENSLACP00000007870	ENSLACP00000011989	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.519
BAMBI	SMAD7	ENSLACP00000007870	ENSLACP00000006551	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.930
BMP4	FGF3	ENSLACP00000021723	ENSLACP00000013990	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.575
BMP4	FGF4	ENSLACP00000021723	ENSLACP00000014225	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.589
BMP4	IHH	ENSLACP00000021723	ENSLACP00000004851	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.543
BMP4	ISL1	ENSLACP00000021723	ENSLACP00000013964	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.425
BMP4	LEF1	ENSLACP00000021723	ENSLACP00000005598	Bone morphogenetic protein 4.	Lymphoid enhancer binding factor 1.	0.502
BMP4	SHH	ENSLACP00000021723	ENSLACP00000013019	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.760
BMP4	SMAD3	ENSLACP00000021723	ENSLACP00000011989	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.499
BMP4	SMAD7	ENSLACP00000021723	ENSLACP00000006551	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.617
CASP3	LOC102347143	ENSLACP00000007386	ENSLACP00000004517	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.494
FGF3	BMP4	ENSLACP00000013990	ENSLACP00000021723	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.575
FGF3	FGF4	ENSLACP00000013990	ENSLACP00000014225	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.731
FGF3	IHH	ENSLACP00000013990	ENSLACP00000004851	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.637
FGF3	LOC102347143	ENSLACP00000013990	ENSLACP00000004517	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.418
FGF3	SHH	ENSLACP00000013990	ENSLACP00000013019	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.703