(26 nodes) (2022) Pathogenic Mechanism of a Highly Virulent Infectious Hematopoietic Necrosis Virus in Head Kidney of Rainbow Trout (Oncorhynchusmykiss) Analyzed by RNA-Seq Transcriptome Profiling. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	IFIH1	Interferon induced with helicase C domain 1. (731 aa)
	FABP1	Fatty acid binding protein 1. (98 aa)
	GOT2	Aspartate aminotransferase. (392 aa)
	CFB	Uncharacterized protein; Belongs to the peptidase S1 family. (764 aa)
	GFPT2	Glutamine-fructose-6-phosphate transaminase 2. (686 aa)
	F13A1	Coagulation factor XIII A chain. (688 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (403 aa)
	AGXT	Serine--pyruvate aminotransferase. (426 aa)
	FBP1	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (359 aa)
	FTCD	Formimidoyltransferase cyclodeaminase. (547 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (798 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (465 aa)
	TBK1	TANK binding kinase 1. (675 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	H3B748_LATCH	Interferon regulatory factor 7. (486 aa)
	C3	Uncharacterized protein. (1286 aa)
	F5	Coagulation factor V; Belongs to the multicopper oxidase family. (1780 aa)
	IRF3	Interferon regulatory factor 3. (481 aa)
	SLC5A1	Solute carrier family 5 member 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (670 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	GLS2	Glutaminase 2. (601 aa)
	IL18	Uncharacterized protein. (200 aa)
	LOC102351715	Uncharacterized protein. (1426 aa)
	C8G	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
	ALDOB	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT	FBP1	ENSLACP00000007350	ENSLACP00000011405	Serine--pyruvate aminotransferase.	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	0.526
AGXT	FTCD	ENSLACP00000007350	ENSLACP00000014032	Serine--pyruvate aminotransferase.	Formimidoyltransferase cyclodeaminase.	0.720
AGXT	GAPDH	ENSLACP00000007350	ENSLACP00000012705	Serine--pyruvate aminotransferase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.518
AGXT	GOT2	ENSLACP00000007350	ENSLACP00000001398	Serine--pyruvate aminotransferase.	Aspartate aminotransferase.	0.615
ALDOB	FBP1	ENSLACP00000022754	ENSLACP00000011405	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	0.974
ALDOB	GAPDH	ENSLACP00000022754	ENSLACP00000012705	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.986
C3	CFB	ENSLACP00000018425	ENSLACP00000003903	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.805
CFB	C3	ENSLACP00000003903	ENSLACP00000018425	Uncharacterized protein; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.805
CFB	LOC102351715	ENSLACP00000003903	ENSLACP00000022402	Uncharacterized protein; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.531
FABP1	GOT2	ENSLACP00000000844	ENSLACP00000001398	Fatty acid binding protein 1.	Aspartate aminotransferase.	0.648
FBP1	AGXT	ENSLACP00000011405	ENSLACP00000007350	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	Serine--pyruvate aminotransferase.	0.526
FBP1	ALDOB	ENSLACP00000011405	ENSLACP00000022754	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.974
FBP1	GAPDH	ENSLACP00000011405	ENSLACP00000012705	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.618
FBP1	GOT2	ENSLACP00000011405	ENSLACP00000001398	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	Aspartate aminotransferase.	0.500
FTCD	AGXT	ENSLACP00000014032	ENSLACP00000007350	Formimidoyltransferase cyclodeaminase.	Serine--pyruvate aminotransferase.	0.720
FTCD	GLS2	ENSLACP00000014032	ENSLACP00000021640	Formimidoyltransferase cyclodeaminase.	Glutaminase 2.	0.813
FTCD	GOT2	ENSLACP00000014032	ENSLACP00000001398	Formimidoyltransferase cyclodeaminase.	Aspartate aminotransferase.	0.808
GAPDH	AGXT	ENSLACP00000012705	ENSLACP00000007350	Glyceraldehyde-3-phosphate dehydrogenase.	Serine--pyruvate aminotransferase.	0.518
GAPDH	ALDOB	ENSLACP00000012705	ENSLACP00000022754	Glyceraldehyde-3-phosphate dehydrogenase.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.986
GAPDH	FBP1	ENSLACP00000012705	ENSLACP00000011405	Glyceraldehyde-3-phosphate dehydrogenase.	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	0.618