(26 nodes) (2023) Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma. network (Latimeria chalumnae)

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proteins of unknown 3D structure

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Your Input:
	IGFBP6	Insulin like growth factor binding protein 6. (271 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	ENO1	Enolase 1. (438 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	PXDN	Peroxidasin. (1149 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
	LDHA	L-lactate dehydrogenase. (362 aa)
	LDHB	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
	ZIC4	Zic family member 4. (525 aa)
	IL6	Uncharacterized protein. (149 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	TFAM	Transcription factor A, mitochondrial. (277 aa)
	IL10	Interleukin 10. (185 aa)
	RPS11	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (158 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (288 aa)
	ATP5F1A	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
	PXDNL	Peroxidasin like. (1276 aa)
	CYTB	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
	COX2	Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (230 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (813 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	HK2	Hexokinase 2. (918 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP5F1A	COX2	ENSLACP00000000021	ENSLACP00000021808	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]	0.763
ATP5F1A	CYTB	ENSLACP00000000021	ENSLACP00000021817	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	0.821
ATP5F1A	ENO1	ENSLACP00000000021	ENSLACP00000017874	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Enolase 1.	0.686
ATP5F1A	IDH1	ENSLACP00000000021	ENSLACP00000016555	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.692
ATP5F1A	LDHA	ENSLACP00000000021	ENSLACP00000011935	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	L-lactate dehydrogenase.	0.601
ATP5F1A	LDHB	ENSLACP00000000021	ENSLACP00000009706	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.675
ATP5F1A	RPS11	ENSLACP00000000021	ENSLACP00000002129	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.	0.965
COX2	ATP5F1A	ENSLACP00000021808	ENSLACP00000000021	Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.763
COX2	CYTB	ENSLACP00000021808	ENSLACP00000021817	Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	0.999
COX2	IDH1	ENSLACP00000021808	ENSLACP00000016555	Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.411
COX2	TFAM	ENSLACP00000021808	ENSLACP00000007086	Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]	Transcription factor A, mitochondrial.	0.498
CYTB	ATP5F1A	ENSLACP00000021817	ENSLACP00000000021	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.821
CYTB	COX2	ENSLACP00000021817	ENSLACP00000021808	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]	0.999
CYTB	LDHA	ENSLACP00000021817	ENSLACP00000011935	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	L-lactate dehydrogenase.	0.415
CYTB	LDHB	ENSLACP00000021817	ENSLACP00000009706	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.415
CYTB	TFAM	ENSLACP00000021817	ENSLACP00000007086	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Transcription factor A, mitochondrial.	0.723
ENO1	ATP5F1A	ENSLACP00000017874	ENSLACP00000000021	Enolase 1.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.686
ENO1	LDHA	ENSLACP00000017874	ENSLACP00000011935	Enolase 1.	L-lactate dehydrogenase.	0.677
ENO1	LDHB	ENSLACP00000017874	ENSLACP00000009706	Enolase 1.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.498
HIF1A	IL6	ENSLACP00000020801	ENSLACP00000009318	Hypoxia inducible factor 1 subunit alpha.	Uncharacterized protein.	0.465