(27 nodes) (2022) Exploration of the Nurse Shark (Ginglymostoma cirratum) Plasma Immunoproteome Using High-Resolution LC-MSMS. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (173 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (185 aa)
	PLG	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	C1S	Complement C1s; Belongs to the peptidase S1 family. (682 aa)
	LOC102351715	Uncharacterized protein. (1426 aa)
	PXDNL	Peroxidasin like. (1276 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (618 aa)
	ANPEP	Aminopeptidase. (980 aa)
	NPEPPS	Aminopeptidase. (879 aa)
	GPX3	Glutathione peroxidase 3. (108 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
	FLRT1	Fibronectin leucine rich transmembrane protein 1. (648 aa)
	C3	Uncharacterized protein. (1286 aa)
	LVRN	Aminopeptidase. (977 aa)
	PROC	Uncharacterized protein. (444 aa)
	VCAM1	Vascular cell adhesion molecule 1. (733 aa)
	LOC102347142	Aminopeptidase. (940 aa)
	H3B037_LATCH	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (112 aa)
	PXDN	Peroxidasin. (1149 aa)
	F10	Coagulation factor X. (475 aa)
	ERAP1	Aminopeptidase. (948 aa)
	PTX3	Uncharacterized protein. (423 aa)
	ENPEP	Aminopeptidase. (952 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (394 aa)
	PREP	Prolyl endopeptidase. (712 aa)
	C1R	Complement C1r; Belongs to the peptidase S1 family. (685 aa)
	LOC102347143	Uncharacterized protein. (612 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANPEP	LOC102347143	ENSLACP00000020847	ENSLACP00000004517	Aminopeptidase.	Uncharacterized protein.	0.420
ANPEP	PREP	ENSLACP00000020847	ENSLACP00000003898	Aminopeptidase.	Prolyl endopeptidase.	0.439
C1R	C1S	ENSLACP00000004208	ENSLACP00000022654	Complement C1r; Belongs to the peptidase S1 family.	Complement C1s; Belongs to the peptidase S1 family.	0.999
C1R	C3	ENSLACP00000004208	ENSLACP00000018425	Complement C1r; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.662
C1R	LOC102351715	ENSLACP00000004208	ENSLACP00000022402	Complement C1r; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.416
C1R	SERPINF2	ENSLACP00000004208	ENSLACP00000003724	Complement C1r; Belongs to the peptidase S1 family.	Serpin family F member 2; Belongs to the serpin family.	0.453
C1S	C1R	ENSLACP00000022654	ENSLACP00000004208	Complement C1s; Belongs to the peptidase S1 family.	Complement C1r; Belongs to the peptidase S1 family.	0.999
C1S	C3	ENSLACP00000022654	ENSLACP00000018425	Complement C1s; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.692
C1S	LOC102351715	ENSLACP00000022654	ENSLACP00000022402	Complement C1s; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.477
C1S	PTX3	ENSLACP00000022654	ENSLACP00000001817	Complement C1s; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.473
C1S	SERPINF2	ENSLACP00000022654	ENSLACP00000003724	Complement C1s; Belongs to the peptidase S1 family.	Serpin family F member 2; Belongs to the serpin family.	0.440
C3	C1R	ENSLACP00000018425	ENSLACP00000004208	Uncharacterized protein.	Complement C1r; Belongs to the peptidase S1 family.	0.662
C3	C1S	ENSLACP00000018425	ENSLACP00000022654	Uncharacterized protein.	Complement C1s; Belongs to the peptidase S1 family.	0.692
C3	F2	ENSLACP00000018425	ENSLACP00000021404	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.499
ENPEP	PREP	ENSLACP00000003105	ENSLACP00000003898	Aminopeptidase.	Prolyl endopeptidase.	0.538
ERAP1	PREP	ENSLACP00000001668	ENSLACP00000003898	Aminopeptidase.	Prolyl endopeptidase.	0.440
F10	F2	ENSLACP00000001289	ENSLACP00000021404	Coagulation factor X.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.822
F2	C3	ENSLACP00000021404	ENSLACP00000018425	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.499
F2	F10	ENSLACP00000021404	ENSLACP00000001289	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor X.	0.822
F2	LOC102347143	ENSLACP00000021404	ENSLACP00000004517	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.672