(12 nodes) (2022) Granulin as an important immune molecule involved in lamprey tissue repair and regeneration by promoting cell proliferation and migration. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	CCND1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	E2F4	E2F transcription factor 4. (228 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	DAXX	Death-domain associated protein. (728 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	DVL1	Dishevelled segment polarity protein 1. (552 aa)
	CREBBP	CREB binding protein. (2411 aa)
	DTX1	Deltex E3 ubiquitin ligase 1. (322 aa)
	FAM171A2	Family with sequence similarity 171 member A2. (840 aa)
	LECT2	Uncharacterized protein. (108 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (938 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCND1	CREBBP	ENSLACP00000014975	ENSLACP00000023096	Cyclin D1; Belongs to the cyclin family.	CREB binding protein.	0.860
CCND1	E2F4	ENSLACP00000014975	ENSLACP00000012458	Cyclin D1; Belongs to the cyclin family.	E2F transcription factor 4.	0.588
CREBBP	CCND1	ENSLACP00000023096	ENSLACP00000014975	CREB binding protein.	Cyclin D1; Belongs to the cyclin family.	0.860
CREBBP	DAXX	ENSLACP00000023096	ENSLACP00000001216	CREB binding protein.	Death-domain associated protein.	0.507
CREBBP	SMAD4	ENSLACP00000023096	ENSLACP00000009312	CREB binding protein.	MH2 domain-containing protein.	0.677
DAXX	CREBBP	ENSLACP00000001216	ENSLACP00000023096	Death-domain associated protein.	CREB binding protein.	0.507
DAXX	SMAD4	ENSLACP00000001216	ENSLACP00000009312	Death-domain associated protein.	MH2 domain-containing protein.	0.493
DLL1	DTX1	ENSLACP00000009351	ENSLACP00000001339	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Deltex E3 ubiquitin ligase 1.	0.577
DTX1	DLL1	ENSLACP00000001339	ENSLACP00000009351	Deltex E3 ubiquitin ligase 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.577
DVL1	LRP6	ENSLACP00000021422	ENSLACP00000020844	Dishevelled segment polarity protein 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.848
E2F4	CCND1	ENSLACP00000012458	ENSLACP00000014975	E2F transcription factor 4.	Cyclin D1; Belongs to the cyclin family.	0.588
E2F4	SMAD4	ENSLACP00000012458	ENSLACP00000009312	E2F transcription factor 4.	MH2 domain-containing protein.	0.963
LRP6	DVL1	ENSLACP00000020844	ENSLACP00000021422	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dishevelled segment polarity protein 1.	0.848
SMAD4	CREBBP	ENSLACP00000009312	ENSLACP00000023096	MH2 domain-containing protein.	CREB binding protein.	0.677
SMAD4	DAXX	ENSLACP00000009312	ENSLACP00000001216	MH2 domain-containing protein.	Death-domain associated protein.	0.493
SMAD4	E2F4	ENSLACP00000009312	ENSLACP00000012458	MH2 domain-containing protein.	E2F transcription factor 4.	0.963