(23 nodes) (2022) Sterile alpha and TIR motif-containing protein 1 is a negative regulator in the anti-bacterial immune responses in nile tilapia (Oreochromis niloticus). network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHCHD2	Coiled-coil-helix-coiled-coil-helix domain containing 2. (107 aa)
	TLR9	Toll-like receptor 9. (1039 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	LOC102355189	Toll-like receptor 18; Belongs to the Toll-like receptor family. (797 aa)
	IRF3	Interferon regulatory factor 3. (481 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	LOC102360389	Tr-type G domain-containing protein. (413 aa)
	LOC102353631-2	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (472 aa)
	CRYBA1	Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (199 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (798 aa)
	PXDN	Peroxidasin. (1149 aa)
	GOSR1	Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. (250 aa)
	SLC46A1	Solute carrier family 46 member 1. (390 aa)
	CPD	Carboxypeptidase D. (1063 aa)
	SCARF1	Scavenger receptor class F member 1. (759 aa)
	FAM98B	Family with sequence similarity 98 member B. (385 aa)
	PRPF8	Pre-mRNA processing factor 8. (2213 aa)
	IL10	Interleukin 10. (185 aa)
	LOC102347143	Uncharacterized protein. (612 aa)
	LOC102356288	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (460 aa)
	LOC102346010	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (465 aa)
	RILP	Rab interacting lysosomal protein. (423 aa)
	PXDNL	Peroxidasin like. (1276 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL10	IRF3	ENSLACP00000005382	ENSLACP00000019335	Interleukin 10.	Interferon regulatory factor 3.	0.496
IL10	LOC102347143	ENSLACP00000005382	ENSLACP00000004517	Interleukin 10.	Uncharacterized protein.	0.548
IL10	LOC102355189	ENSLACP00000005382	ENSLACP00000020140	Interleukin 10.	Toll-like receptor 18; Belongs to the Toll-like receptor family.	0.492
IL10	MYD88	ENSLACP00000005382	ENSLACP00000019094	Interleukin 10.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.796
IL10	TLR2	ENSLACP00000005382	ENSLACP00000014305	Interleukin 10.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.667
IL10	TLR9	ENSLACP00000005382	ENSLACP00000020965	Interleukin 10.	Toll-like receptor 9.	0.650
IRF3	IL10	ENSLACP00000019335	ENSLACP00000005382	Interferon regulatory factor 3.	Interleukin 10.	0.496
IRF3	MYD88	ENSLACP00000019335	ENSLACP00000019094	Interferon regulatory factor 3.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.882
IRF3	TIRAP	ENSLACP00000019335	ENSLACP00000020333	Interferon regulatory factor 3.	TIR domain containing adaptor protein.	0.590
IRF3	TLR2	ENSLACP00000019335	ENSLACP00000014305	Interferon regulatory factor 3.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.466
IRF3	TLR9	ENSLACP00000019335	ENSLACP00000020965	Interferon regulatory factor 3.	Toll-like receptor 9.	0.732
LOC102347143	IL10	ENSLACP00000004517	ENSLACP00000005382	Uncharacterized protein.	Interleukin 10.	0.548
LOC102347143	PXDN	ENSLACP00000004517	ENSLACP00000014158	Uncharacterized protein.	Peroxidasin.	0.761
LOC102347143	PXDNL	ENSLACP00000004517	ENSLACP00000022207	Uncharacterized protein.	Peroxidasin like.	0.761
LOC102355189	IL10	ENSLACP00000020140	ENSLACP00000005382	Toll-like receptor 18; Belongs to the Toll-like receptor family.	Interleukin 10.	0.492
LOC102355189	MYD88	ENSLACP00000020140	ENSLACP00000019094	Toll-like receptor 18; Belongs to the Toll-like receptor family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.959
LOC102355189	TIRAP	ENSLACP00000020140	ENSLACP00000020333	Toll-like receptor 18; Belongs to the Toll-like receptor family.	TIR domain containing adaptor protein.	0.955
LOC102355189	TLR2	ENSLACP00000020140	ENSLACP00000014305	Toll-like receptor 18; Belongs to the Toll-like receptor family.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.912
MYD88	IL10	ENSLACP00000019094	ENSLACP00000005382	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Interleukin 10.	0.796
MYD88	IRF3	ENSLACP00000019094	ENSLACP00000019335	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Interferon regulatory factor 3.	0.882