(7 nodes) (2022) IL11 stimulates ERKP90RSK to inhibit LKB1AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL6	Uncharacterized protein. (149 aa)
	NOX4	NADPH oxidase 4. (541 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (359 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAF	STAT3	ENSLACP00000012774	ENSLACP00000013656	B-Raf proto-oncogene, serine/threonine kinase.	Signal transducer and activator of transcription.	0.552
GAPDH	IL6	ENSLACP00000012705	ENSLACP00000009318	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein.	0.522
GAPDH	STAT3	ENSLACP00000012705	ENSLACP00000013656	Glyceraldehyde-3-phosphate dehydrogenase.	Signal transducer and activator of transcription.	0.513
H3B8U3_LATCH	MTOR	ENSLACP00000018314	ENSLACP00000018843	Serine/threonine-protein kinase TOR.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.944
H3B8U3_LATCH	STAT3	ENSLACP00000018314	ENSLACP00000013656	Serine/threonine-protein kinase TOR.	Signal transducer and activator of transcription.	0.566
IL6	GAPDH	ENSLACP00000009318	ENSLACP00000012705	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.522
IL6	STAT3	ENSLACP00000009318	ENSLACP00000013656	Uncharacterized protein.	Signal transducer and activator of transcription.	0.933
MTOR	H3B8U3_LATCH	ENSLACP00000018843	ENSLACP00000018314	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.944
MTOR	STAT3	ENSLACP00000018843	ENSLACP00000013656	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Signal transducer and activator of transcription.	0.633
STAT3	BRAF	ENSLACP00000013656	ENSLACP00000012774	Signal transducer and activator of transcription.	B-Raf proto-oncogene, serine/threonine kinase.	0.552
STAT3	GAPDH	ENSLACP00000013656	ENSLACP00000012705	Signal transducer and activator of transcription.	Glyceraldehyde-3-phosphate dehydrogenase.	0.513
STAT3	H3B8U3_LATCH	ENSLACP00000013656	ENSLACP00000018314	Signal transducer and activator of transcription.	Serine/threonine-protein kinase TOR.	0.566
STAT3	IL6	ENSLACP00000013656	ENSLACP00000009318	Signal transducer and activator of transcription.	Uncharacterized protein.	0.933
STAT3	MTOR	ENSLACP00000013656	ENSLACP00000018843	Signal transducer and activator of transcription.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.633