(21 nodes) (2022) Grouper TRIM23 exerts antiviral activity against iridovirus and nodavirus. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	TRAF4	TNF receptor-associated factor. (434 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
	H3APL3_LATCH	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (534 aa)
	TRIM25	Tripartite motif containing 25. (657 aa)
	H3AZ94_LATCH	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	TRIM13	Tripartite motif containing 13. (414 aa)
	TRAF1	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (565 aa)
	TBK1	TANK binding kinase 1. (675 aa)
	TRIM23	Tripartite motif containing 23. (583 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
	H3B748_LATCH	Interferon regulatory factor 7. (486 aa)
	H3B7S8_LATCH	TNF receptor-associated factor. (449 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	TRIM62	B30.2/SPRY domain-containing protein. (312 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	TRIM32	Tripartite motif containing 32. (647 aa)
	LOC102351730	RING-type domain-containing protein. (353 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3APL3_LATCH	H3B748_LATCH	ENSLACP00000011584	ENSLACP00000017719	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Interferon regulatory factor 7.	0.543
H3APL3_LATCH	H3B7S8_LATCH	ENSLACP00000011584	ENSLACP00000017949	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor.	0.559
H3APL3_LATCH	MYD88	ENSLACP00000011584	ENSLACP00000019094	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.575
H3APL3_LATCH	TBK1	ENSLACP00000011584	ENSLACP00000015869	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TANK binding kinase 1.	0.721
H3APL3_LATCH	TLR3	ENSLACP00000011584	ENSLACP00000012956	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.524
H3APL3_LATCH	TRAF1	ENSLACP00000011584	ENSLACP00000015272	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.546
H3APL3_LATCH	TRAF2	ENSLACP00000011584	ENSLACP00000011356	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.553
H3APL3_LATCH	TRAF6	ENSLACP00000011584	ENSLACP00000003556	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.822
H3AZ94_LATCH	H3B748_LATCH	ENSLACP00000014965	ENSLACP00000017719	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Interferon regulatory factor 7.	0.617
H3AZ94_LATCH	H3B7S8_LATCH	ENSLACP00000014965	ENSLACP00000017949	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor.	0.651
H3AZ94_LATCH	MYD88	ENSLACP00000014965	ENSLACP00000019094	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.744
H3AZ94_LATCH	TBK1	ENSLACP00000014965	ENSLACP00000015869	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TANK binding kinase 1.	0.829
H3AZ94_LATCH	TLR3	ENSLACP00000014965	ENSLACP00000012956	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.677
H3AZ94_LATCH	TRAF1	ENSLACP00000014965	ENSLACP00000015272	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.646
H3AZ94_LATCH	TRAF2	ENSLACP00000014965	ENSLACP00000011356	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.640
H3AZ94_LATCH	TRAF5	ENSLACP00000014965	ENSLACP00000017309	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.698
H3AZ94_LATCH	TRAF6	ENSLACP00000014965	ENSLACP00000003556	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.878
H3AZ94_LATCH	TRIM23	ENSLACP00000014965	ENSLACP00000015891	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Tripartite motif containing 23.	0.425
H3B748_LATCH	H3APL3_LATCH	ENSLACP00000017719	ENSLACP00000011584	Interferon regulatory factor 7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.543
H3B748_LATCH	H3AZ94_LATCH	ENSLACP00000017719	ENSLACP00000014965	Interferon regulatory factor 7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.617