(28 nodes) (2023) Investigation of the Molecular Evolution of Treg Suppression Mechanisms Indicates a Convergent Origin. network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	TNFAIP3	TNF alpha induced protein 3. (785 aa)
	JDP2	Jun dimerization protein 2. (164 aa)
	IL6R	Interleukin 6 receptor. (469 aa)
	TNFAIP2	TNF alpha induced protein 2. (665 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (928 aa)
	LOC102346386	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (166 aa)
	GZMA	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (210 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (287 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (655 aa)
	NFATC1	Nuclear factor of activated T cells 1. (455 aa)
	BATF3	Basic leucine zipper ATF-like transcription factor 3. (74 aa)
	GATA3	GATA binding protein 3. (447 aa)
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	LOC102346637	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (264 aa)
	TNFAIP6	TNF alpha induced protein 6. (279 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (517 aa)
	RORC	RAR related orphan receptor C. (502 aa)
	H3A6A5_LATCH	Serine/threonine-protein phosphatase. (522 aa)
	IL10	Interleukin 10. (185 aa)
	CTLA4	IG domain-containing protein. (186 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
	TLL1	Tolloid like 1. (667 aa)
	NT5M	5',3'-nucleotidase, mitochondrial. (242 aa)
	LAG3	Uncharacterized protein. (328 aa)
	CBL	Cbl proto-oncogene. (903 aa)
	NT5C1A	5'-nucleotidase, cytosolic IA. (371 aa)
	TNFRSF21	TNF receptor superfamily member 21. (651 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF3	IRF4	ENSLACP00000003303	ENSLACP00000017263	Basic leucine zipper ATF-like transcription factor 3.	Interferon regulatory factor 4.	0.528
CD40	CTLA4	ENSLACP00000004148	ENSLACP00000010132	TNFR-Cys domain-containing protein.	IG domain-containing protein.	0.755
CD40	IL10	ENSLACP00000004148	ENSLACP00000005382	TNFR-Cys domain-containing protein.	Interleukin 10.	0.712
CTLA4	CD40	ENSLACP00000010132	ENSLACP00000004148	IG domain-containing protein.	TNFR-Cys domain-containing protein.	0.755
CTLA4	IL10	ENSLACP00000010132	ENSLACP00000005382	IG domain-containing protein.	Interleukin 10.	0.699
CTLA4	LAG3	ENSLACP00000010132	ENSLACP00000011798	IG domain-containing protein.	Uncharacterized protein.	0.678
GATA3	IL10	ENSLACP00000003446	ENSLACP00000005382	GATA binding protein 3.	Interleukin 10.	0.616
GATA3	IRF4	ENSLACP00000003446	ENSLACP00000017263	GATA binding protein 3.	Interferon regulatory factor 4.	0.434
GATA3	RORC	ENSLACP00000003446	ENSLACP00000020228	GATA binding protein 3.	RAR related orphan receptor C.	0.471
H3A6A5_LATCH	NFATC1	ENSLACP00000005176	ENSLACP00000001999	Serine/threonine-protein phosphatase.	Nuclear factor of activated T cells 1.	0.673
IL10	CD40	ENSLACP00000005382	ENSLACP00000004148	Interleukin 10.	TNFR-Cys domain-containing protein.	0.712
IL10	CTLA4	ENSLACP00000005382	ENSLACP00000010132	Interleukin 10.	IG domain-containing protein.	0.699
IL10	GATA3	ENSLACP00000005382	ENSLACP00000003446	Interleukin 10.	GATA binding protein 3.	0.616
IL10	IL6R	ENSLACP00000005382	ENSLACP00000022612	Interleukin 10.	Interleukin 6 receptor.	0.546
IL10	LAG3	ENSLACP00000005382	ENSLACP00000011798	Interleukin 10.	Uncharacterized protein.	0.446
IL10	PPARG	ENSLACP00000005382	ENSLACP00000010456	Interleukin 10.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.617
IL10	TNFAIP6	ENSLACP00000005382	ENSLACP00000004893	Interleukin 10.	TNF alpha induced protein 6.	0.552
IL6R	IL10	ENSLACP00000022612	ENSLACP00000005382	Interleukin 6 receptor.	Interleukin 10.	0.546
IRF4	BATF3	ENSLACP00000017263	ENSLACP00000003303	Interferon regulatory factor 4.	Basic leucine zipper ATF-like transcription factor 3.	0.528
IRF4	GATA3	ENSLACP00000017263	ENSLACP00000003446	Interferon regulatory factor 4.	GATA binding protein 3.	0.434