(17 nodes) (2023) Enhanced insulin activity achieved in VDRab ablation zebrafish. network (Latimeria chalumnae)

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Your Input:
	UCP2	Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	CPT2	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (665 aa)
	TRPV6	Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (538 aa)
	ELOVL5	Elongation of very long chain fatty acids protein. (219 aa)
	H3ACE0_LATCH	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	CPT1B	Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (729 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
	CYP2R1	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (439 aa)
	INSR	Uncharacterized protein. (270 aa)
	PDIA3	Protein disulfide-isomerase. (497 aa)
	CYP24A1	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (505 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	CYP27A1	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (539 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (502 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPT1B	PPARG	ENSLACP00000008053	ENSLACP00000010456	Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.443
CYP24A1	CYP27B1	ENSLACP00000015931	ENSLACP00000020555	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.916
CYP24A1	CYP2R1	ENSLACP00000015931	ENSLACP00000011303	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family.	0.941
CYP27A1	CYP2R1	ENSLACP00000019759	ENSLACP00000011303	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family.	0.494
CYP27B1	CYP24A1	ENSLACP00000020555	ENSLACP00000015931	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	0.916
CYP27B1	CYP2R1	ENSLACP00000020555	ENSLACP00000011303	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family.	0.951
CYP2R1	CYP24A1	ENSLACP00000011303	ENSLACP00000015931	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	0.941
CYP2R1	CYP27A1	ENSLACP00000011303	ENSLACP00000019759	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family.	0.494
CYP2R1	CYP27B1	ENSLACP00000011303	ENSLACP00000020555	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.951
H3ACE0_LATCH	INSR	ENSLACP00000007311	ENSLACP00000011313	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.805
H3ACE0_LATCH	PCK1	ENSLACP00000007311	ENSLACP00000020448	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Phosphoenolpyruvate carboxykinase 1.	0.426
H3ACE0_LATCH	PDIA3	ENSLACP00000007311	ENSLACP00000015133	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein disulfide-isomerase.	0.570
H3ACE0_LATCH	PPARG	ENSLACP00000007311	ENSLACP00000010456	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.799
H3ACE0_LATCH	UCP1	ENSLACP00000007311	ENSLACP00000007314	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.514
H3B8U3_LATCH	MTOR	ENSLACP00000018314	ENSLACP00000018843	Serine/threonine-protein kinase TOR.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.944
INSR	H3ACE0_LATCH	ENSLACP00000011313	ENSLACP00000007311	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.805
MTOR	H3B8U3_LATCH	ENSLACP00000018843	ENSLACP00000018314	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.944
PCK1	H3ACE0_LATCH	ENSLACP00000020448	ENSLACP00000007311	Phosphoenolpyruvate carboxykinase 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.426
PDIA3	H3ACE0_LATCH	ENSLACP00000015133	ENSLACP00000007311	Protein disulfide-isomerase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.570
PPARG	CPT1B	ENSLACP00000010456	ENSLACP00000008053	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family.	0.443