(20 nodes) (2023) Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102367521	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (798 aa)
	LOC102357450	Uncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
	IL10	Interleukin 10. (185 aa)
	RHEB	Ras homolog, mTORC1 binding. (184 aa)
	KEAP1	Kelch like ECH associated protein 1. (588 aa)
	BAX	Uncharacterized protein. (223 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (290 aa)
	GSR	Glutathione reductase. (290 aa)
	LOC102350473	Tyrosine hydroxylase 2. (425 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	TSC2	TSC complex subunit 2. (1836 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (430 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (313 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	BNIP3	BCL2 interacting protein 3. (202 aa)
	APAF1	Apoptotic peptidase activating factor 1. (1202 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAX	ENSLACP00000014568	ENSLACP00000007049	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.800
APAF1	BNIP3	ENSLACP00000014568	ENSLACP00000014880	Apoptotic peptidase activating factor 1.	BCL2 interacting protein 3.	0.404
APAF1	CASP3	ENSLACP00000014568	ENSLACP00000007386	Apoptotic peptidase activating factor 1.	Caspase 3; Belongs to the peptidase C14A family.	0.930
APAF1	CASP7	ENSLACP00000014568	ENSLACP00000022676	Apoptotic peptidase activating factor 1.	Caspase 7; Belongs to the peptidase C14A family.	0.877
APAF1	LOC102357450	ENSLACP00000014568	ENSLACP00000014115	Apoptotic peptidase activating factor 1.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.400
APAF1	LOC102367521	ENSLACP00000014568	ENSLACP00000014331	Apoptotic peptidase activating factor 1.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.864
ATG5	BNIP3	ENSLACP00000015035	ENSLACP00000014880	Autophagy protein 5; Involved in autophagic vesicle formation.	BCL2 interacting protein 3.	0.465
ATG5	CASP3	ENSLACP00000015035	ENSLACP00000007386	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 3; Belongs to the peptidase C14A family.	0.527
ATG5	H3B8U3_LATCH	ENSLACP00000015035	ENSLACP00000018314	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase TOR.	0.453
ATG5	MTOR	ENSLACP00000015035	ENSLACP00000018843	Autophagy protein 5; Involved in autophagic vesicle formation.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.453
ATG5	RHEB	ENSLACP00000015035	ENSLACP00000013733	Autophagy protein 5; Involved in autophagic vesicle formation.	Ras homolog, mTORC1 binding.	0.517
ATG5	TSC2	ENSLACP00000015035	ENSLACP00000000293	Autophagy protein 5; Involved in autophagic vesicle formation.	TSC complex subunit 2.	0.552
BAX	APAF1	ENSLACP00000007049	ENSLACP00000014568	Uncharacterized protein.	Apoptotic peptidase activating factor 1.	0.800
BAX	CASP3	ENSLACP00000007049	ENSLACP00000007386	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.553
BAX	LOC102367521	ENSLACP00000007049	ENSLACP00000014331	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.432
BNIP3	APAF1	ENSLACP00000014880	ENSLACP00000014568	BCL2 interacting protein 3.	Apoptotic peptidase activating factor 1.	0.404
BNIP3	ATG5	ENSLACP00000014880	ENSLACP00000015035	BCL2 interacting protein 3.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.465
BNIP3	RHEB	ENSLACP00000014880	ENSLACP00000013733	BCL2 interacting protein 3.	Ras homolog, mTORC1 binding.	0.941
CASP3	APAF1	ENSLACP00000007386	ENSLACP00000014568	Caspase 3; Belongs to the peptidase C14A family.	Apoptotic peptidase activating factor 1.	0.930
CASP3	ATG5	ENSLACP00000007386	ENSLACP00000015035	Caspase 3; Belongs to the peptidase C14A family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.527