STRINGSTRING
UQCRFS1 UQCRFS1 KRAS KRAS TGFB1 TGFB1 NOTCH1 NOTCH1 LOC102352268 LOC102352268 RND1 RND1 TGFB3 TGFB3 KLF4 KLF4 DDX5 DDX5 LOC102363109 LOC102363109 LOC102357987 LOC102357987 STAT3 STAT3 BRAF BRAF DNMT1 DNMT1 SMAD3 SMAD3 DPYSL4 DPYSL4 MDM2 MDM2 ACTR3 ACTR3 EP300 EP300 TGFB2 TGFB2 SOX2 SOX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UQCRFS1Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (277 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
NOTCH1Notch receptor 1. (2494 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
RND1Rho family GTPase 1. (321 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
KLF4Kruppel like factor 4. (429 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (512 aa)
LOC102363109Destrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (168 aa)
LOC102357987Uncharacterized protein. (2519 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
DNMT1DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1273 aa)
SMAD3Mothers against decapentaplegic homolog. (358 aa)
DPYSL4Dihydropyrimidinase like 4. (692 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (485 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
EP300E1A binding protein p300. (1119 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
SOX2SRY-box transcription factor 2. (315 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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