(16 nodes) (2023) Genome-wide association study reveals genomic loci of sex differentiation and gonadal development in Plectropomus leopardus. network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	DMRT3	Doublesex and mab-3 related transcription factor 3. (484 aa)
	HSD3B7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (377 aa)
	SGK1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
	USF1	Upstream transcription factor 1. (293 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1077 aa)
	TET3	Tet methylcytosine dioxygenase 3. (1688 aa)
	FOXO1	Forkhead box O1. (633 aa)
	FRYL	FRY like transcription coactivator. (3020 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
	FAM102A	Family with sequence similarity 102 member A. (412 aa)
	TAF7	TATA-box binding protein associated factor 7. (366 aa)
	DDX6	DEAD-box helicase 6; Belongs to the DEAD box helicase family. (485 aa)
	SOX9	SRY-box transcription factor 9. (475 aa)
	LOC102351715	Uncharacterized protein. (1426 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DMRT3	FAM102A	ENSLACP00000013660	ENSLACP00000018593	Doublesex and mab-3 related transcription factor 3.	Family with sequence similarity 102 member A.	0.577
DMRT3	SOX9	ENSLACP00000013660	ENSLACP00000021343	Doublesex and mab-3 related transcription factor 3.	SRY-box transcription factor 9.	0.458
FAM102A	DMRT3	ENSLACP00000018593	ENSLACP00000013660	Family with sequence similarity 102 member A.	Doublesex and mab-3 related transcription factor 3.	0.577
FOXO1	SGK1	ENSLACP00000011598	ENSLACP00000001028	Forkhead box O1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.458
GLI3	IHH	ENSLACP00000004224	ENSLACP00000004851	GLI family zinc finger 3.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.573
IHH	GLI3	ENSLACP00000004851	ENSLACP00000004224	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	GLI family zinc finger 3.	0.573
IHH	SOX9	ENSLACP00000004851	ENSLACP00000021343	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	SRY-box transcription factor 9.	0.617
SGK1	FOXO1	ENSLACP00000001028	ENSLACP00000011598	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1.	0.458
SOX9	DMRT3	ENSLACP00000021343	ENSLACP00000013660	SRY-box transcription factor 9.	Doublesex and mab-3 related transcription factor 3.	0.458
SOX9	IHH	ENSLACP00000021343	ENSLACP00000004851	SRY-box transcription factor 9.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.617