(17 nodes) (2023) The Immune Response to the Myxozoan Parasite Myxobolus cerebralis in Salmonids: A Review on Whirling Disease. network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRSS35	Serine protease; Belongs to the peptidase S1B family. (379 aa)
	LOC102354780	Serine protease; Belongs to the peptidase S1B family. (370 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	SOCS1	Suppressor of cytokine signaling 1a. (190 aa)
	PRSS23	Serine protease; Belongs to the peptidase S1B family. (382 aa)
	IL17C	Uncharacterized protein. (190 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	JAK1	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (613 aa)
	STAT1	Signal transducer and activator of transcription. (1179 aa)
	IL10	Interleukin 10. (185 aa)
	IRF1	Interferon regulatory factor. (264 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	ARG2	Arginase. (363 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	SOCS3	Suppressor of cytokine signaling 3. (205 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG2	IL10	ENSLACP00000020265	ENSLACP00000005382	Arginase.	Interleukin 10.	0.711
ARG2	NOS2	ENSLACP00000020265	ENSLACP00000020145	Arginase.	Nitric oxide synthase; Produces nitric oxide (NO).	0.941
IL10	ARG2	ENSLACP00000005382	ENSLACP00000020265	Interleukin 10.	Arginase.	0.711
IL10	IL17C	ENSLACP00000005382	ENSLACP00000008474	Interleukin 10.	Uncharacterized protein.	0.408
IL10	JAK1	ENSLACP00000005382	ENSLACP00000007727	Interleukin 10.	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.525
IL10	SOCS1	ENSLACP00000005382	ENSLACP00000009341	Interleukin 10.	Suppressor of cytokine signaling 1a.	0.614
IL10	SOCS3	ENSLACP00000005382	ENSLACP00000019685	Interleukin 10.	Suppressor of cytokine signaling 3.	0.629
IL10	STAT1	ENSLACP00000005382	ENSLACP00000007692	Interleukin 10.	Signal transducer and activator of transcription.	0.635
IL10	STAT3	ENSLACP00000005382	ENSLACP00000013656	Interleukin 10.	Signal transducer and activator of transcription.	0.821
IL10	TGFB1	ENSLACP00000005382	ENSLACP00000020652	Interleukin 10.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.726
IL17C	IL10	ENSLACP00000008474	ENSLACP00000005382	Uncharacterized protein.	Interleukin 10.	0.408
IRF1	JAK1	ENSLACP00000001728	ENSLACP00000007727	Interferon regulatory factor.	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.535
IRF1	SOCS1	ENSLACP00000001728	ENSLACP00000009341	Interferon regulatory factor.	Suppressor of cytokine signaling 1a.	0.663
IRF1	SOCS3	ENSLACP00000001728	ENSLACP00000019685	Interferon regulatory factor.	Suppressor of cytokine signaling 3.	0.506
IRF1	STAT1	ENSLACP00000001728	ENSLACP00000007692	Interferon regulatory factor.	Signal transducer and activator of transcription.	0.825
IRF1	STAT3	ENSLACP00000001728	ENSLACP00000013656	Interferon regulatory factor.	Signal transducer and activator of transcription.	0.748
JAK1	IL10	ENSLACP00000007727	ENSLACP00000005382	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Interleukin 10.	0.525
JAK1	IRF1	ENSLACP00000007727	ENSLACP00000001728	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Interferon regulatory factor.	0.535
JAK1	SOCS1	ENSLACP00000007727	ENSLACP00000009341	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Suppressor of cytokine signaling 1a.	0.914
JAK1	SOCS3	ENSLACP00000007727	ENSLACP00000019685	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Suppressor of cytokine signaling 3.	0.984