(81 nodes) Tyrosine kinase, catalytic domain network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TEK	TEK receptor tyrosine kinase. (914 aa)
	TEC	Tyrosine-protein kinase. (662 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1394 aa)
	FGFR4	Fibroblast growth factor receptor. (810 aa)
	BMX	Tyrosine-protein kinase. (677 aa)
	MAP3K10	Mitogen-activated protein kinase kinase kinase. (998 aa)
	AXL	AXL receptor tyrosine kinase. (872 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
	BTK	Tyrosine-protein kinase. (646 aa)
	FGR	Tyrosine-protein kinase. (535 aa)
	NTRK3	Tyrosine-protein kinase receptor. (296 aa)
	YES1	Tyrosine-protein kinase. (539 aa)
	NTRK1	Tyrosine-protein kinase receptor. (747 aa)
	FES	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
	ABL1	Tyrosine-protein kinase. (1156 aa)
	INSRR	Tyrosine-protein kinase receptor. (323 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1250 aa)
	PDGFRB	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
	ITK	Tyrosine-protein kinase. (624 aa)
	CSF1R	Colony stimulating factor 1 receptor. (968 aa)
	EPHB3	EPH receptor B3. (996 aa)
	LOC102356668	Uncharacterized protein. (671 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1067 aa)
	LOC102363504	Tyrosine-protein kinase. (1116 aa)
	FGFR1	Fibroblast growth factor receptor. (824 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1385 aa)
	MATK	Tyrosine-protein kinase. (447 aa)
	H3AYV3_LATCH	Uncharacterized protein. (962 aa)
	LCK	Tyrosine-protein kinase. (512 aa)
	H3AYQ4_LATCH	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1220 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	EPHA5	Uncharacterized protein. (743 aa)
	LOC102359081	Protein kinase domain-containing protein. (372 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (838 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (923 aa)
	EPHA2	Uncharacterized protein. (979 aa)
	LOC102356870	Uncharacterized protein. (744 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	ROS1	Tyrosine-protein kinase receptor. (2138 aa)
	H3ANX7_LATCH	Uncharacterized protein. (553 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (897 aa)
	PDGFRA	Uncharacterized protein. (1094 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1. (769 aa)
	MAP3K9	Mitogen-activated protein kinase kinase kinase. (900 aa)
	CSK	Tyrosine-protein kinase. (452 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	LOC102348760	Uncharacterized protein. (782 aa)
	IGF1R	Insulin like growth factor 1 receptor. (1170 aa)
	JAK1	Janus kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (613 aa)
	EPHA4	EPH receptor A4. (985 aa)
	H3AD06_LATCH	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (684 aa)
	EPHA3	Uncharacterized protein. (552 aa)
	FGFR2	Fibroblast growth factor receptor. (810 aa)
	SRC	Tyrosine-protein kinase. (535 aa)
	TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1143 aa)
	JAK2	Tyrosine-protein kinase. (1152 aa)
	H3AAW0_LATCH	Tyrosine kinase, non-receptor, 2b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1069 aa)
	LYN	Tyrosine-protein kinase. (515 aa)
	EPHB6	EPH receptor B6. (974 aa)
	ABL2	Tyrosine-protein kinase. (1175 aa)
	H3A7S0_LATCH	Mitogen-activated protein kinase kinase kinase 21; Belongs to the protein kinase superfamily. (391 aa)
	EPHA10	Uncharacterized protein. (732 aa)
	LOC102358202	Tyrosine-protein kinase receptor. (838 aa)
	RET	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1090 aa)
	SRMS	Tyrosine-protein kinase. (497 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	EPHA7	EPH receptor A7. (903 aa)
	BLK	Tyrosine-protein kinase. (447 aa)
	TXK	Tyrosine-protein kinase. (426 aa)
	NTRK2	Tyrosine-protein kinase receptor. (819 aa)
	H2ZZG8_LATCH	Tyrosine-protein kinase. (396 aa)
	DDR1	Discoidin domain receptor tyrosine kinase 1. (964 aa)
	LOC102355101	Uncharacterized protein. (690 aa)
	RYK	Receptor like tyrosine kinase. (542 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (882 aa)
	ERBB3	Protein kinase domain-containing protein. (1047 aa)
	LOC102363060	Tyrosine-protein kinase receptor. (1012 aa)
	FGFR3	Fibroblast growth factor receptor. (778 aa)
	FRK	Tyrosine-protein kinase. (782 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (876 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSLACP00000017765	ENSLACP00000006377	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	ABL1	ENSLACP00000006377	ENSLACP00000017765	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
AXL	LYN	ENSLACP00000020423	ENSLACP00000006462	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.404
AXL	SRC	ENSLACP00000020423	ENSLACP00000007324	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.407
AXL	YES1	ENSLACP00000020423	ENSLACP00000018713	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.407
BLK	CSK	ENSLACP00000003363	ENSLACP00000008751	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.701
BLK	ERBB2	ENSLACP00000003363	ENSLACP00000016970	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.468
BLK	ERBB3	ENSLACP00000003363	ENSLACP00000001477	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.468
BLK	FES	ENSLACP00000003363	ENSLACP00000017834	Tyrosine-protein kinase.	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	0.405
BLK	H2ZZG8_LATCH	ENSLACP00000003363	ENSLACP00000002789	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.452
BLK	MATK	ENSLACP00000003363	ENSLACP00000014862	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.702
BLK	MET	ENSLACP00000003363	ENSLACP00000015263	Tyrosine-protein kinase.	MET proto-oncogene, receptor tyrosine kinase.	0.625
BLK	PDGFRB	ENSLACP00000003363	ENSLACP00000016550	Tyrosine-protein kinase.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.444
BLK	PTK2B	ENSLACP00000003363	ENSLACP00000000176	Tyrosine-protein kinase.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.614
BLK	SYK	ENSLACP00000003363	ENSLACP00000012982	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.510
BLK	ZAP70	ENSLACP00000003363	ENSLACP00000008633	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.536
BMX	CSF1R	ENSLACP00000021868	ENSLACP00000016266	Tyrosine-protein kinase.	Colony stimulating factor 1 receptor.	0.423
BMX	KIT	ENSLACP00000021868	ENSLACP00000004383	Tyrosine-protein kinase.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.407
BMX	LYN	ENSLACP00000021868	ENSLACP00000006462	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.696
BMX	MET	ENSLACP00000021868	ENSLACP00000015263	Tyrosine-protein kinase.	MET proto-oncogene, receptor tyrosine kinase.	0.616