(18 nodes) Breast cancer carboxy-terminal domain network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BARD1	BRCA1 associated RING domain 1. (866 aa)
	PES1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (584 aa)
	DBF4	DBF4 zinc finger. (672 aa)
	ECT2	Epithelial cell transforming 2. (919 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1270 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (2149 aa)
	H3AC16_LATCH	X-ray repair complementing defective repair in Chinese hamster cells 1. (649 aa)
	CHD1L	Chromodomain helicase DNA binding protein 1 like. (1017 aa)
	BRCA1	BRCA1 DNA repair associated. (1873 aa)
	PAXIP1	PAX interacting protein 1. (1219 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1542 aa)
	PARP4	Poly [ADP-ribose] polymerase. (1731 aa)
	LIG4	DNA ligase. (911 aa)
	RFC1	Replication factor C subunit 1. (1152 aa)
	H2ZXR2_LATCH	Ligase III, DNA, ATP-dependent; Belongs to the ATP-dependent DNA ligase family. (960 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (846 aa)
	DNTT	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (487 aa)
	POLL	DNA polymerase lambda; Belongs to the DNA polymerase type-X family. (572 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BRCA1	ENSLACP00000022324	ENSLACP00000006740	BRCA1 associated RING domain 1.	BRCA1 DNA repair associated.	0.999
BARD1	CTDP1	ENSLACP00000022324	ENSLACP00000002160	BRCA1 associated RING domain 1.	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	0.403
BARD1	LIG4	ENSLACP00000022324	ENSLACP00000003688	BRCA1 associated RING domain 1.	DNA ligase.	0.705
BARD1	PAXIP1	ENSLACP00000022324	ENSLACP00000006504	BRCA1 associated RING domain 1.	PAX interacting protein 1.	0.921
BARD1	PES1	ENSLACP00000022324	ENSLACP00000019460	BRCA1 associated RING domain 1.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.603
BARD1	REV1	ENSLACP00000022324	ENSLACP00000011946	BRCA1 associated RING domain 1.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.448
BARD1	RFC1	ENSLACP00000022324	ENSLACP00000003355	BRCA1 associated RING domain 1.	Replication factor C subunit 1.	0.705
BARD1	TOPBP1	ENSLACP00000022324	ENSLACP00000006236	BRCA1 associated RING domain 1.	DNA topoisomerase II binding protein 1.	0.983
BARD1	TP53BP1	ENSLACP00000022324	ENSLACP00000009837	BRCA1 associated RING domain 1.	Tumor protein p53 binding protein 1.	0.887
BRCA1	BARD1	ENSLACP00000006740	ENSLACP00000022324	BRCA1 DNA repair associated.	BRCA1 associated RING domain 1.	0.999
BRCA1	CTDP1	ENSLACP00000006740	ENSLACP00000002160	BRCA1 DNA repair associated.	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	0.488
BRCA1	H3AC16_LATCH	ENSLACP00000006740	ENSLACP00000007187	BRCA1 DNA repair associated.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.437
BRCA1	LIG4	ENSLACP00000006740	ENSLACP00000003688	BRCA1 DNA repair associated.	DNA ligase.	0.611
BRCA1	PAXIP1	ENSLACP00000006740	ENSLACP00000006504	BRCA1 DNA repair associated.	PAX interacting protein 1.	0.898
BRCA1	PES1	ENSLACP00000006740	ENSLACP00000019460	BRCA1 DNA repair associated.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.453
BRCA1	REV1	ENSLACP00000006740	ENSLACP00000011946	BRCA1 DNA repair associated.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.429
BRCA1	RFC1	ENSLACP00000006740	ENSLACP00000003355	BRCA1 DNA repair associated.	Replication factor C subunit 1.	0.620
BRCA1	TOPBP1	ENSLACP00000006740	ENSLACP00000006236	BRCA1 DNA repair associated.	DNA topoisomerase II binding protein 1.	0.986
BRCA1	TP53BP1	ENSLACP00000006740	ENSLACP00000009837	BRCA1 DNA repair associated.	Tumor protein p53 binding protein 1.	0.957
CHD1L	H3AC16_LATCH	ENSLACP00000007056	ENSLACP00000007187	Chromodomain helicase DNA binding protein 1 like.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.641