(26 nodes) Nicotinate and nicotinamide metabolism network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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	ASPDH	Aspartate dehydrogenase domain containing. (285 aa)
	LOC102356827	Uncharacterized protein. (205 aa)
	QPRT	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (324 aa)
	LOC102357063	Uncharacterized protein. (367 aa)
	NAMPT	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (492 aa)
	LOC102362277	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (541 aa)
	NMNAT1	Nicotinamide-nucleotide adenylyltransferase. (286 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	NT5C	5', 3'-nucleotidase, cytosolic. (199 aa)
	AOX1	FAD-binding PCMH-type domain-containing protein. (1070 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (310 aa)
	NMNAT2	Nicotinamide nucleotide adenylyltransferase 2. (202 aa)
	LOC102349693	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (293 aa)
	SIRT6	Sirtuin 6. (375 aa)
	SIRT7	Sirtuin 7. (413 aa)
	NT5DC4	5'-nucleotidase domain containing 4. (475 aa)
	NT5M	5',3'-nucleotidase, mitochondrial. (242 aa)
	NMRK1	Nicotinamide riboside kinase 1. (212 aa)
	NADK2	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. (427 aa)
	NT5C1A	5'-nucleotidase, cytosolic IA. (371 aa)
	NUDT12	Nudix hydrolase 12. (460 aa)
	H3BDU0_LATCH	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (318 aa)
	SIRT4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (315 aa)
	NADK	NAD kinase. (308 aa)
	PNP	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (309 aa)
	LOC102352541	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (286 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOX1	LOC102349693	ENSLACP00000007573	ENSLACP00000008793	FAD-binding PCMH-type domain-containing protein.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.489
AOX1	LOC102352541	ENSLACP00000007573	ENSLACP00000022271	FAD-binding PCMH-type domain-containing protein.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.489
AOX1	PNP	ENSLACP00000007573	ENSLACP00000021970	FAD-binding PCMH-type domain-containing protein.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.489
H3BDU0_LATCH	LOC102349693	ENSLACP00000020061	ENSLACP00000008793	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.907
H3BDU0_LATCH	LOC102352541	ENSLACP00000020061	ENSLACP00000022271	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.907
H3BDU0_LATCH	NADK	ENSLACP00000020061	ENSLACP00000021769	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD kinase.	0.921
H3BDU0_LATCH	NADK2	ENSLACP00000020061	ENSLACP00000012506	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	0.900
H3BDU0_LATCH	NAMPT	ENSLACP00000020061	ENSLACP00000005041	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.925
H3BDU0_LATCH	NMNAT1	ENSLACP00000020061	ENSLACP00000005960	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Nicotinamide-nucleotide adenylyltransferase.	0.918
H3BDU0_LATCH	NMNAT2	ENSLACP00000020061	ENSLACP00000008447	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Nicotinamide nucleotide adenylyltransferase 2.	0.918
H3BDU0_LATCH	NUDT12	ENSLACP00000020061	ENSLACP00000017711	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Nudix hydrolase 12.	0.914
H3BDU0_LATCH	PNP	ENSLACP00000020061	ENSLACP00000021970	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.907
H3BDU0_LATCH	SIRT4	ENSLACP00000020061	ENSLACP00000020887	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.628
H3BDU0_LATCH	SIRT5	ENSLACP00000020061	ENSLACP00000008319	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.667
H3BDU0_LATCH	SIRT6	ENSLACP00000020061	ENSLACP00000008822	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 6.	0.436
LOC102349693	AOX1	ENSLACP00000008793	ENSLACP00000007573	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	FAD-binding PCMH-type domain-containing protein.	0.489
LOC102349693	H3BDU0_LATCH	ENSLACP00000008793	ENSLACP00000020061	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.907
LOC102349693	LOC102352541	ENSLACP00000008793	ENSLACP00000022271	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.901
LOC102349693	LOC102356827	ENSLACP00000008793	ENSLACP00000002476	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	Uncharacterized protein.	0.918
LOC102349693	LOC102357063	ENSLACP00000008793	ENSLACP00000003656	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	Uncharacterized protein.	0.916