(33 nodes) Drug metabolism - other enzymes network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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	UMPS	Uridine monophosphate synthetase. (290 aa)
	LOC102346260	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (313 aa)
	H3A1M4_LATCH	Uncharacterized protein. (457 aa)
	DPYS	Dihydropyrimidinase. (514 aa)
	LOC102350392	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (214 aa)
	NME6	Nucleoside diphosphate kinase. (188 aa)
	LOC102363528	Glutathione S-transferase mu, tandem duplicate 1; Belongs to the GST superfamily. (220 aa)
	NME1	Nucleoside diphosphate kinase. (172 aa)
	UCK2	Uridine-cytidine kinase 2. (180 aa)
	GMPS	Guanine monophosphate synthase. (683 aa)
	RRM1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (763 aa)
	IMPDH1	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (515 aa)
	CMPK1	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (213 aa)
	MGST3	Microsomal glutathione S-transferase 3. (146 aa)
	MGST1	Microsomal glutathione S-transferase 1. (155 aa)
	DPYD	Pyr_redox_2 domain-containing protein. (333 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (389 aa)
	LOC102367628	Glutathione S-transferase theta 2; Belongs to the GST superfamily. (242 aa)
	MGST2	Microsomal glutathione S-transferase 2. (147 aa)
	LOC102359351	Uncharacterized protein; Belongs to the GST superfamily. (193 aa)
	TYMP	Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (474 aa)
	NME3	NME/NM23 nucleoside diphosphate kinase 3; Belongs to the NDK family. (131 aa)
	UGT1A1	UDP glucuronosyltransferase family 1 member A1; Belongs to the UDP-glycosyltransferase family. (538 aa)
	NME7	Nucleoside diphosphate kinase 7; Belongs to the NDK family. (376 aa)
	GSTP1	Glutathione S-transferase pi 1. (215 aa)
	TK1	Thymidine kinase. (239 aa)
	LOC102347787	Sushi domain-containing protein. (742 aa)
	LOC102348047	Sushi domain-containing protein. (802 aa)
	HPRT1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa)
	UCK1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (270 aa)
	GUSB	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (714 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (145 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDA	DPYD	ENSLACP00000022824	ENSLACP00000012665	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Pyr_redox_2 domain-containing protein.	0.642
CDA	GMPS	ENSLACP00000022824	ENSLACP00000008506	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Guanine monophosphate synthase.	0.485
CDA	RRM1	ENSLACP00000022824	ENSLACP00000009301	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.601
CDA	TK1	ENSLACP00000022824	ENSLACP00000018385	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Thymidine kinase.	0.996
CDA	TYMP	ENSLACP00000022824	ENSLACP00000014557	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.	0.998
CDA	UCK1	ENSLACP00000022824	ENSLACP00000019878	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.972
CDA	UCK2	ENSLACP00000022824	ENSLACP00000007116	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uridine-cytidine kinase 2.	0.972
CDA	UMPS	ENSLACP00000022824	ENSLACP00000000039	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uridine monophosphate synthetase.	0.715
CDA	UPP1	ENSLACP00000022824	ENSLACP00000003085	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.999
CMPK1	GMPS	ENSLACP00000011560	ENSLACP00000008506	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Guanine monophosphate synthase.	0.441
CMPK1	NME1	ENSLACP00000011560	ENSLACP00000006479	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Nucleoside diphosphate kinase.	0.929
CMPK1	NME3	ENSLACP00000011560	ENSLACP00000014806	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	NME/NM23 nucleoside diphosphate kinase 3; Belongs to the NDK family.	0.929
CMPK1	NME6	ENSLACP00000011560	ENSLACP00000006323	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Nucleoside diphosphate kinase.	0.929
CMPK1	NME7	ENSLACP00000011560	ENSLACP00000016390	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Nucleoside diphosphate kinase 7; Belongs to the NDK family.	0.931
CMPK1	RRM1	ENSLACP00000011560	ENSLACP00000009301	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.946
CMPK1	RRM2	ENSLACP00000011560	ENSLACP00000012813	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Ribonucleotide reductase regulatory subunit M2.	0.924
CMPK1	TK1	ENSLACP00000011560	ENSLACP00000018385	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Thymidine kinase.	0.922
CMPK1	UCK1	ENSLACP00000011560	ENSLACP00000019878	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.935
CMPK1	UCK2	ENSLACP00000011560	ENSLACP00000007116	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Uridine-cytidine kinase 2.	0.950
CMPK1	UMPS	ENSLACP00000011560	ENSLACP00000000039	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Uridine monophosphate synthetase.	0.946