STRINGSTRING
CHEK2 CHEK2 WEE1 WEE1 CDC16 CDC16 ORC4 ORC4 SMC1A SMC1A BUB3 BUB3 CCNA2 CCNA2 LOC102356560 LOC102356560 YWHAZ YWHAZ LOC102367471 LOC102367471 H2ZXS9_LATCH H2ZXS9_LATCH CCNE1 CCNE1 CCNB2 CCNB2 RBL2 RBL2 CUL1 CUL1 FZR1 FZR1 GADD45A GADD45A E2F5 E2F5 CDK6 CDK6 PLK1 PLK1 GADD45G GADD45G MCM7 MCM7 RB1 RB1 ATM ATM ANAPC11 ANAPC11 RBX1 RBX1 CDK4 CDK4 ORC6 ORC6 YWHAG YWHAG CDKN2C CDKN2C PCNA PCNA TFDP2 TFDP2 YWHAB YWHAB TGFB2 TGFB2 E2F1 E2F1 CCNB1 CCNB1 SMAD2 SMAD2 CCNA1 CCNA1 WEE2 WEE2 MAD2L1 MAD2L1 ORC3 ORC3 SMAD4 SMAD4 CDKN1A CDKN1A E2F2 E2F2 MCM6 MCM6 GADD45B GADD45B CDC7 CDC7 ATR ATR STAG1 STAG1 CDC14B CDC14B PTTG1 PTTG1 MDM2 MDM2 RBL1 RBL1 YWHAQ YWHAQ SMAD3 SMAD3 SMC3 SMC3 E2F4 E2F4 MCM2 MCM2 TFDP1 TFDP1 GSK3B GSK3B ANAPC1 ANAPC1 SKP2 SKP2 CDKN1B CDKN1B LOC102366718 LOC102366718 ANAPC13 ANAPC13 CCND1 CCND1 LOC102345953 LOC102345953 ANAPC10 ANAPC10 ORC5 ORC5 MCM4 MCM4 CDKN2D CDKN2D CDKN1C CDKN1C ANAPC2 ANAPC2 TP53 TP53 CDC14A CDC14A ORC2 ORC2 RAD21 RAD21 CCNB3 CCNB3 CDC45 CDC45 CDC27 CDC27 E2F3 E2F3 ABL1 ABL1 STAG2 STAG2 ANAPC7 ANAPC7 SKP1 SKP1 TGFB3 TGFB3 CHEK1 CHEK1 LOC102352268 LOC102352268 CDC23 CDC23 YWHAH YWHAH ANAPC5 ANAPC5 CDK2 CDK2 BUB1 BUB1 CDK1 CDK1 TTK TTK PKMYT1 PKMYT1 LOC102358988 LOC102358988 MAD1L1 MAD1L1 CDC26 CDC26 CREBBP CREBBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHEK2Checkpoint kinase 2. (411 aa)
WEE1WEE1 G2 checkpoint kinase. (382 aa)
CDC16Cell division cycle 16. (545 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (360 aa)
SMC1AStructural maintenance of chromosomes protein. (1234 aa)
BUB3BUB3 mitotic checkpoint protein. (361 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (447 aa)
LOC102356560ANK_REP_REGION domain-containing protein. (128 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa)
LOC102367471Uncharacterized protein; Belongs to the cyclin family. (292 aa)
H2ZXS9_LATCHCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (417 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (404 aa)
RBL2RB transcriptional corepressor like 2. (1109 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (155 aa)
E2F5E2F transcription factor 5. (378 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (322 aa)
PLK1Serine/threonine-protein kinase PLK. (595 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (160 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (614 aa)
RB1Uncharacterized protein. (411 aa)
ATMATM serine/threonine kinase. (2375 aa)
ANAPC11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
RBX1Ring-box 1. (108 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)
ORC6Origin recognition complex subunit 6. (257 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (169 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
TFDP2Transcription factor. (450 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (244 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
E2F1E2F transcription factor 1. (411 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (404 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (433 aa)
WEE2Wee1-like protein kinase. (515 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (202 aa)
ORC3Origin recognition complex subunit 3. (720 aa)
SMAD4MH2 domain-containing protein. (412 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (171 aa)
E2F2E2F transcription factor 2. (435 aa)
MCM6DNA helicase; Belongs to the MCM family. (826 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (158 aa)
CDC7Cell division cycle 7. (560 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2654 aa)
STAG1Stromal antigen 1. (1258 aa)
CDC14BCell division cycle 14B. (459 aa)
PTTG1Uncharacterized protein. (171 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (485 aa)
RBL1RB transcriptional corepressor like 1. (1084 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (154 aa)
SMAD3Mothers against decapentaplegic homolog. (358 aa)
SMC3Structural maintenance of chromosomes protein. (1222 aa)
E2F4E2F transcription factor 4. (228 aa)
MCM2DNA helicase; Belongs to the MCM family. (888 aa)
TFDP1Transcription factor. (412 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
ANAPC1Anaphase promoting complex subunit 1. (1891 aa)
SKP2S-phase kinase associated protein 2. (423 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
LOC102366718Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (327 aa)
ANAPC13Anaphase promoting complex subunit 13. (75 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
LOC102345953Cyclin D3; Belongs to the cyclin family. (292 aa)
ANAPC10Anaphase promoting complex subunit 10. (147 aa)
ORC5Origin recognition complex subunit 5. (264 aa)
MCM4DNA helicase; Belongs to the MCM family. (858 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (168 aa)
CDKN1CUncharacterized protein. (215 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (816 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
CDC14AUncharacterized protein. (612 aa)
ORC2Origin recognition complex subunit 2. (568 aa)
RAD21RAD21 cohesin complex component. (630 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (416 aa)
CDC45Cell division cycle 45. (609 aa)
CDC27Cell division cycle 27. (833 aa)
E2F3E2F transcription factor 3. (340 aa)
ABL1Tyrosine-protein kinase. (1156 aa)
STAG2Stromal antigen 2. (1284 aa)
ANAPC7Anaphase promoting complex subunit 7. (565 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (172 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
CDC23Cell division cycle 23. (581 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (247 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1272 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
TTKTTK protein kinase. (889 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1. (563 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (684 aa)
CDC26Cell division cycle 26. (85 aa)
CREBBPCREB binding protein. (2411 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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