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CHEK2 CHEK2 TSC2 TSC2 LOC102345199 LOC102345199 IGFBP3 IGFBP3 CASP10 CASP10 LOC102367471 LOC102367471 H2ZXS9_LATCH H2ZXS9_LATCH CCNE1 CCNE1 RCHY1 RCHY1 CCNB2 CCNB2 CCNG2 CCNG2 GADD45A GADD45A SIVA1 SIVA1 CDK6 CDK6 GADD45G GADD45G ATM ATM CDK4 CDK4 LOC102363280 LOC102363280 PTEN PTEN BAX BAX CASP3 CASP3 LOC102362452 LOC102362452 CCNB1 CCNB1 CDKN1A CDKN1A LOC102356692 LOC102356692 GADD45B GADD45B ATR ATR MDM2 MDM2 GORAB GORAB CCNG1 CCNG1 COP1 COP1 LOC102359041 LOC102359041 RRM2 RRM2 LOC102366718 LOC102366718 APAF1 APAF1 CCND1 CCND1 LOC102361707 LOC102361707 LOC102345953 LOC102345953 LOC102361982 LOC102361982 TP53 TP53 SIAH1 SIAH1 ZMAT3 ZMAT3 EI24 EI24 CHEK1 CHEK1 PPM1D PPM1D SESN2 SESN2 MDM4 MDM4 STEAP3 STEAP3 CD82 CD82 THBS1 THBS1 SHISA5 SHISA5 CDK2 CDK2 TP73 TP73 H3BIN7_LATCH H3BIN7_LATCH CDK1 CDK1 M3XHT8_LATCH M3XHT8_LATCH GTSE1 GTSE1 IGF1 IGF1 TP53I3 TP53I3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHEK2Checkpoint kinase 2. (411 aa)
TSC2TSC complex subunit 2. (1836 aa)
LOC102345199Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (115 aa)
IGFBP3Insulin like growth factor binding protein 3. (288 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (539 aa)
LOC102367471Uncharacterized protein; Belongs to the cyclin family. (292 aa)
H2ZXS9_LATCHCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (417 aa)
RCHY1Uncharacterized protein. (238 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (404 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (348 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (155 aa)
SIVA1SIVA1 apoptosis inducing factor. (168 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (322 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (160 aa)
ATMATM serine/threonine kinase. (2375 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)
LOC102363280Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
BAXUncharacterized protein. (223 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (290 aa)
LOC102362452Uncharacterized protein. (176 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (404 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (171 aa)
LOC102356692Si:zfos-80g12.1. (503 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (158 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2654 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (485 aa)
GORABGolgin, RAB6 interacting. (378 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (296 aa)
COP1COP1 E3 ubiquitin ligase. (702 aa)
LOC102359041Zgc:153993. (208 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (389 aa)
LOC102366718Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (327 aa)
APAF1Apoptotic peptidase activating factor 1. (1202 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
LOC102361707P53 apoptosis effector related to pmp22. (183 aa)
LOC102345953Cyclin D3; Belongs to the cyclin family. (292 aa)
LOC102361982Uncharacterized protein. (182 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
ZMAT3Zinc finger matrin-type 3. (363 aa)
EI24EI24 autophagy associated transmembrane protein. (340 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (636 aa)
SESN2Sestrin 2. (463 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
STEAP3STEAP3 metalloreductase. (488 aa)
CD82Tetraspanin. (257 aa)
THBS1Thrombospondin 1. (1170 aa)
SHISA5Shisa family member 5. (156 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
H3BIN7_LATCHUncharacterized protein. (107 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
M3XHT8_LATCHUncharacterized protein. (197 aa)
GTSE1GTSE1_N domain-containing protein. (721 aa)
IGF1Insulin like growth factor 1. (136 aa)
TP53I3Tumor protein p53 inducible protein 3. (334 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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