STRINGSTRING
TSC2 TSC2 LOC102354262 LOC102354262 FZD8 FZD8 FZD4 FZD4 RNF152 RNF152 ULK2 ULK2 FNIP1 FNIP1 H2ZYH3_LATCH H2ZYH3_LATCH PRKCB PRKCB ATP6V1G2 ATP6V1G2 ATP6V1F ATP6V1F ATP6V1C2 ATP6V1C2 PRKAA1 PRKAA1 LOC102356269 LOC102356269 LAMTOR4 LAMTOR4 ATP6V1B1 ATP6V1B1 SOS1 SOS1 LOC102348524 LOC102348524 PRKCA PRKCA AKT1 AKT1 LAMTOR3 LAMTOR3 WNT7A WNT7A SLC38A9 SLC38A9 WNT9B WNT9B RICTOR RICTOR PRKAA2 PRKAA2 PTEN PTEN WNT5A WNT5A WNT11 WNT11 ATP6V1E1 ATP6V1E1 CAB39 CAB39 CHUK CHUK MAP2K1 MAP2K1 NPRL3 NPRL3 RAF1 RAF1 IGF1R IGF1R WNT16 WNT16 RPS6KA1 RPS6KA1 STRADB STRADB LOC102348007 LOC102348007 WNT3 WNT3 EIF4EBP1 EIF4EBP1 MIOS MIOS ATP6V1A ATP6V1A CAB39L CAB39L EIF4E EIF4E TTI1 TTI1 RRAGD RRAGD LOC102356355 LOC102356355 FLCN FLCN ATP6V1D ATP6V1D RPS6KA6 RPS6KA6 MAP2K2 MAP2K2 RPS6 RPS6 CASTOR1 CASTOR1 H3ARU2_LATCH H3ARU2_LATCH LAMTOR2 LAMTOR2 GSK3B GSK3B TBC1D7 TBC1D7 FZD3 FZD3 ATP6V1G1 ATP6V1G1 SKP2 SKP2 RHEB RHEB DEPTOR DEPTOR LPIN2 LPIN2 FZD1 FZD1 PIK3CB PIK3CB STRADA STRADA PRR5 PRR5 PIK3R1 PIK3R1 SEC13 SEC13 MAPK1 MAPK1 FZD7 FZD7 IRS1 IRS1 FZD6 FZD6 DVL3 DVL3 SLC7A5 SLC7A5 WNT8A WNT8A WNT4 WNT4 H3B5C9_LATCH H3B5C9_LATCH PIK3CA PIK3CA WNT2 WNT2 WDR24 WDR24 NPRL2 NPRL2 LOC102366268 LOC102366268 LOC102365238 LOC102365238 RRAGB RRAGB LOC102363206 LOC102363206 MLST8 MLST8 MTOR MTOR WNT9A WNT9A WNT10A WNT10A RHOA RHOA ATP6V1H ATP6V1H WNT6 WNT6 SESN2 SESN2 WNT3A WNT3A EIF4B EIF4B DDIT4 DDIT4 WNT5B WNT5B FZD2 FZD2 MAPKAP1 MAPKAP1 AKT1S1 AKT1S1 WNT2B WNT2B LRP6 LRP6 LAMTOR5 LAMTOR5 HRAS HRAS NRAS NRAS LRP5 LRP5 DVL1 DVL1 FZD10 FZD10 FZD9 FZD9 RHEBL1 RHEBL1 WNT1 WNT1 LOC102350297 LOC102350297 WNT10B WNT10B AKT3 AKT3 IGF1 IGF1 KRAS KRAS RPTOR RPTOR LOC102352322 LOC102352322 PDPK1 PDPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSC2TSC complex subunit 2. (1836 aa)
LOC102354262Mitogen-activated protein kinase. (330 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (530 aa)
RNF152Ring finger protein 152. (203 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1040 aa)
FNIP1Folliculin interacting protein 1. (1156 aa)
H2ZYH3_LATCHProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (93 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (121 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (391 aa)
PRKAA1Non-specific serine/threonine protein kinase. (552 aa)
LOC102356269Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (103 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (392 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
LOC102348524Uncharacterized protein. (193 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (577 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (478 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1664 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1a. (212 aa)
CAB39Calcium binding protein 39. (341 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (700 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (396 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (396 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
IGF1RInsulin like growth factor 1 receptor. (1170 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (712 aa)
STRADBSTE20 related adaptor beta. (421 aa)
LOC102348007Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (392 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (113 aa)
MIOSMeiosis regulator for oocyte development. (877 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
TTI1TELO2 interacting protein 1. (1099 aa)
RRAGDRas related GTP binding D. (398 aa)
LOC102356355TNFR-Cys domain-containing protein. (163 aa)
FLCNFolliculin. (576 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (247 aa)
RPS6KA6Ribosomal protein S6 kinase. (726 aa)
MAP2K2Mitogen-activated protein kinase kinase 2a. (301 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (136 aa)
H3ARU2_LATCHUncharacterized protein. (152 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (604 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (152 aa)
SKP2S-phase kinase associated protein 2. (423 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
DEPTORDEP domain containing MTOR interacting protein. (369 aa)
LPIN2Lipin 2. (906 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
STRADASTE20 related adaptor alpha. (432 aa)
PRR5Uncharacterized protein. (599 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
IRS1Insulin receptor substrate 1. (1076 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
SLC7A5Solute carrier family 7 member 5. (522 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
H3B5C9_LATCHProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WDR24WD repeat domain 24. (790 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
LOC102366268LNS2 domain-containing protein. (999 aa)
LOC102365238Ribosomal protein S6 kinase. (740 aa)
RRAGBRas-related GTP binding A. (313 aa)
LOC102363206Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
RHOAUncharacterized protein. (193 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (496 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
SESN2Sestrin 2. (463 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
EIF4BEukaryotic translation initiation factor 4B. (651 aa)
DDIT4DNA damage inducible transcript 4. (222 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
MAPKAP1MAPK associated protein 1. (523 aa)
AKT1S1AKT1 substrate 1. (285 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (92 aa)
HRASHRas proto-oncogene, GTPase. (193 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1598 aa)
DVL1Dishevelled segment polarity protein 1. (552 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
RHEBL1Ras homolog, mTORC1 binding like 1. (184 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
LOC102350297Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
IGF1Insulin like growth factor 1. (136 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1334 aa)
LOC102352322Aamy domain-containing protein. (520 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (563 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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