STRINGSTRING
PIK3R6 PIK3R6 LOC102360076 LOC102360076 ATP1A2 ATP1A2 CACNA2D3 CACNA2D3 PLCB4 PLCB4 LOC102354262 LOC102354262 ATP1A1 ATP1A1 MAPK14 MAPK14 ADRA1A ADRA1A TNNI3 TNNI3 ADRA1D ADRA1D SLC8A1-2 SLC8A1-2 CACNG2 CACNG2 SCN10A SCN10A PPP2R2B PPP2R2B ADRB2 ADRB2 LOC102364634 LOC102364634 ATF4 ATF4 ADCY4 ADCY4 PRKCA PRKCA AKT1 AKT1 SCN1B SCN1B LOC102361286 LOC102361286 ATP1B3 ATP1B3 LOC102353242 LOC102353242 ADCY5-2 ADCY5-2 AGTR1 AGTR1 LOC102348461 LOC102348461 RAPGEF4 RAPGEF4 ATP1B4 ATP1B4 ADCY9 ADCY9 ATP2B3 ATP2B3 LOC102362951 LOC102362951 CACNG7 CACNG7 PIK3CG PIK3CG GNAI1 GNAI1 CREB3 CREB3 PPP2R5B PPP2R5B H3AHJ4_LATCH H3AHJ4_LATCH CREB3L2 CREB3L2 MYL3 MYL3 CREM CREM CACNG5 CACNG5 CREB3L3 CREB3L3 PPP1CA PPP1CA AGTR2 AGTR2 LOC102350821 LOC102350821 LOC102359594 LOC102359594 CACNG4 CACNG4 ATP2A1 ATP2A1 LOC102353564 LOC102353564 ADCY8 ADCY8 PLCB1 PLCB1 ADRB1 ADRB1 CACNG1 CACNG1 PPP1CB PPP1CB LOC102367281 LOC102367281 TNNT2 TNNT2 LOC102362971 LOC102362971 RPS6KA5 RPS6KA5 TPM2 TPM2 LOC102361424 LOC102361424 RYR2 RYR2 ACTC1 ACTC1 PPP2R1A PPP2R1A MYH7 MYH7 PPP2R3A PPP2R3A PPP2R2C PPP2R2C ADRA1B ADRA1B PRKACB PRKACB MYH6 MYH6 TPM1 TPM1 CACNB4 CACNB4 GNAS GNAS PPP2R2D PPP2R2D PPP2R3B PPP2R3B LOC106703183 LOC106703183 LOC102345989 LOC102345989 SLC8A2 SLC8A2 MAPK1 MAPK1 ATP1B1 ATP1B1 KCNE1 KCNE1 SLC8A3 SLC8A3 CACNA2D2 CACNA2D2 CACNG3 CACNG3 CACNB1 CACNB1 CREB5 CREB5 MYL2 MYL2 PPP1CC PPP1CC MAPK11 MAPK11 CACNB2 CACNB2 CALML4 CALML4 MAPK12 MAPK12 PPP2CA PPP2CA CACNA1C CACNA1C CACNB3 CACNB3 ADCY6 ADCY6 PPP2R2A PPP2R2A PPP2R5E PPP2R5E CACNA1S CACNA1S LOC102367479 LOC102367479 GNAI3 GNAI3 PPP2R3C PPP2R3C TNNC1 TNNC1 PPP2R1B PPP2R1B LOC102359098 LOC102359098 CALML6 CALML6 LOC102347381 LOC102347381 ATP2A2 ATP2A2 AKT3 AKT3 PPP2R5D PPP2R5D CACNA2D4 CACNA2D4 PPP2R5C PPP2R5C AGT AGT
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (503 aa)
LOC102360076Protein kinase domain-containing protein. (286 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (780 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (999 aa)
PLCB4Phosphoinositide phospholipase C. (919 aa)
LOC102354262Mitogen-activated protein kinase. (330 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1033 aa)
MAPK14Mitogen-activated protein kinase. (399 aa)
ADRA1AAdrenoceptor alpha 1A. (459 aa)
TNNI3Uncharacterized protein. (240 aa)
ADRA1DAdrenoceptor alpha 1D; Belongs to the G-protein coupled receptor 1 family. (309 aa)
SLC8A1-2J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (603 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (225 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1202 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (432 aa)
ADRB2Adrenoceptor beta 2. (432 aa)
LOC102364634Uncharacterized protein. (377 aa)
ATF4Activating transcription factor 4. (374 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1092 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (577 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (478 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (221 aa)
LOC102361286Calmodulin 2; Belongs to the calmodulin family. (149 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
LOC102353242Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1171 aa)
ADCY5-2AC_N domain-containing protein. (323 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
LOC102348461G_PROTEIN_RECEP_F1_2 domain-containing protein. (373 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (750 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (324 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1340 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1259 aa)
LOC102362951Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (302 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
GNAI1G protein subunit alpha i1. (326 aa)
CREB3cAMP responsive element binding protein 3. (452 aa)
PPP2R5BSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (495 aa)
H3AHJ4_LATCHIon_trans domain-containing protein; Belongs to the potassium channel family. (298 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (408 aa)
MYL3Myosin, light chain 13. (195 aa)
CREMcAMP responsive element modulator. (331 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (329 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (344 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
LOC102350821Serine/threonine-protein phosphatase. (309 aa)
LOC102359594Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (329 aa)
ATP2A1ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1013 aa)
LOC102353564Uncharacterized protein. (161 aa)
ADCY8AC_N domain-containing protein. (266 aa)
PLCB1Phosphoinositide phospholipase C. (1034 aa)
ADRB1Adrenoceptor beta 1. (394 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (226 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
LOC102367281Solute carrier family 8 member 4b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (968 aa)
TNNT2Troponin T2, cardiac type. (286 aa)
LOC102362971Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1081 aa)
RPS6KA5Ribosomal protein S6 kinase. (767 aa)
TPM2Tropomyosin 2; Belongs to the tropomyosin family. (284 aa)
LOC102361424Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a. (355 aa)
RYR2Ryanodine receptor 2b (cardiac). (3465 aa)
ACTC1Zgc:86709. (377 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (591 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1936 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1165 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
ADRA1BAdrenoceptor alpha 1B. (473 aa)
PRKACBUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1936 aa)
TPM1Alpha-tropomyosin; Belongs to the tropomyosin family. (328 aa)
CACNB4Calcium channel, voltage-dependent, beta 4a subunit. (477 aa)
GNASGNAS complex locus. (377 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (588 aa)
LOC106703183C2H2-type domain-containing protein. (189 aa)
LOC102345989Uncharacterized protein. (92 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (914 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (305 aa)
KCNE1Uncharacterized protein. (122 aa)
SLC8A3Solute carrier family 8 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (589 aa)
CACNA2D2VWFA domain-containing protein. (800 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (246 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (625 aa)
CREB5cAMP responsive element binding protein 5. (288 aa)
MYL2Myosin light chain 2. (148 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (548 aa)
CALML4Calmodulin like 4. (165 aa)
MAPK12Uncharacterized protein. (103 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2064 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (486 aa)
ADCY6Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (451 aa)
PPP2R5ESerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (467 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1866 aa)
LOC102367479Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (992 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (451 aa)
TNNC1Troponin C type 1a (slow). (164 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (589 aa)
LOC102359098Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1180 aa)
CALML6Calmodulin like 6. (160 aa)
LOC102347381Uncharacterized protein. (187 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1007 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
PPP2R5DSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (619 aa)
CACNA2D4VGCC_alpha2 domain-containing protein. (170 aa)
PPP2R5CSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (610 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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