(37 nodes) VEGF signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP3CA	Serine/threonine-protein phosphatase. (287 aa)
	LOC102354262	Mitogen-activated protein kinase. (330 aa)
	MAPK14	Mitogen-activated protein kinase. (399 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
	PLA2G4F	Phospholipase A2. (785 aa)
	PRKCA	Protein kinase C alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (577 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (478 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (517 aa)
	LOC102351732	Uncharacterized protein. (192 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (396 aa)
	SRC	Tyrosine-protein kinase. (535 aa)
	SHC2	SHC (Src homology 2 domain containing) transforming protein 2. (633 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (219 aa)
	LOC102348007	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (392 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (620 aa)
	SPHK2	Sphingosine kinase 2. (479 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2a. (301 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	H3ARU2_LATCH	Uncharacterized protein. (152 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
	RAC1	Rac family small GTPase 1. (192 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	MAPK11	Mitogen-activated protein kinase. (361 aa)
	CDC42	Cell division cycle 42. (156 aa)
	MAPK12	Uncharacterized protein. (103 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (386 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1219 aa)
	RAC3	Rac family small GTPase 3. (148 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
	NFATC2	Nuclear factor of activated T cells 2. (912 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	LOC102352006	Uncharacterized protein. (163 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	ENSLACP00000005002	ENSLACP00000022625	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT1	CDC42	ENSLACP00000005002	ENSLACP00000018010	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cell division cycle 42.	0.489
AKT1	HSPB1	ENSLACP00000005002	ENSLACP00000008229	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	0.514
AKT1	KRAS	ENSLACP00000005002	ENSLACP00000022976	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	KRAS proto-oncogene, GTPase.	0.437
AKT1	LOC102348007	ENSLACP00000005002	ENSLACP00000008684	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	0.961
AKT1	LOC102351732	ENSLACP00000005002	ENSLACP00000006235	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.409
AKT1	LOC102354262	ENSLACP00000005002	ENSLACP00000001400	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.922
AKT1	MAPK1	ENSLACP00000005002	ENSLACP00000015867	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.929
AKT1	MAPK14	ENSLACP00000005002	ENSLACP00000001774	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.417
AKT1	NRAS	ENSLACP00000005002	ENSLACP00000020975	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	NRAS proto-oncogene, GTPase.	0.405
AKT1	PIK3CA	ENSLACP00000005002	ENSLACP00000017606	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.954
AKT1	PIK3CB	ENSLACP00000005002	ENSLACP00000014968	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.956
AKT1	PIK3R1	ENSLACP00000005002	ENSLACP00000015476	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.961
AKT1	RAC1	ENSLACP00000005002	ENSLACP00000015032	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Rac family small GTPase 1.	0.409
AKT1	RAC3	ENSLACP00000005002	ENSLACP00000022054	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Rac family small GTPase 3.	0.409
AKT1	SRC	ENSLACP00000005002	ENSLACP00000007324	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.526
AKT3	AKT1	ENSLACP00000022625	ENSLACP00000005002	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT3	CDC42	ENSLACP00000022625	ENSLACP00000018010	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cell division cycle 42.	0.489
AKT3	HSPB1	ENSLACP00000022625	ENSLACP00000008229	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	0.514
AKT3	LOC102348007	ENSLACP00000022625	ENSLACP00000008684	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	0.974