(100 nodes) Apelin signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6. (503 aa)
	LOC102353790	Uncharacterized protein. (899 aa)
	GNG12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	CCN2	Cellular communication network factor 2. (344 aa)
	GABARAPL1	GABA type A receptor associated protein like 1. (87 aa)
	PLCB4	Phosphoinositide phospholipase C. (919 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	LOC102354262	Mitogen-activated protein kinase. (330 aa)
	LOC102365300	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	LOC102367471	Uncharacterized protein; Belongs to the cyclin family. (292 aa)
	CAMK4	Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (373 aa)
	SLC8A1-2	J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (603 aa)
	LOC102352251	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (460 aa)
	NOTCH3	Notch receptor 3. (1577 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (552 aa)
	GABARAPL2	GABA type A receptor associated protein like 2. (117 aa)
	ACTG2	Actin gamma 2, smooth muscle. (353 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1092 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (478 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (268 aa)
	ACTA2	Uncharacterized protein. (338 aa)
	LOC102361286	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (505 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	PRKCE	Protein kinase C, epsilon b. (347 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (553 aa)
	ADCY5-2	AC_N domain-containing protein. (323 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	TFAM	Transcription factor A, mitochondrial. (277 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (396 aa)
	H3ACJ0_LATCH	Cellular communication network factor 2b. (348 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1340 aa)
	GNG7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	LOC102362951	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	GABARAPL1-2	Uncharacterized protein. (117 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
	NOS1	Nitric oxide synthase 1. (1476 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	TGFBR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	GNAI1	G protein subunit alpha i1. (326 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
	MEF2D	Myocyte enhancer factor 2D. (486 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	SPHK2	Sphingosine kinase 2. (479 aa)
	GNG8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	MYL3	Myosin, light chain 13. (195 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2a. (301 aa)
	MRAS	Uncharacterized protein. (208 aa)
	PDE3B	Phosphodiesterase. (1104 aa)
	ADCY8	AC_N domain-containing protein. (266 aa)
	PLCB1	Phosphoinositide phospholipase C. (1034 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1363 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	SMAD3	Mothers against decapentaplegic homolog. (358 aa)
	RYR3	Uncharacterized protein. (3558 aa)
	H3ARU2_LATCH	Uncharacterized protein. (152 aa)
	LOC102367281	Solute carrier family 8 member 4b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (968 aa)
	LOC102362971	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1081 aa)
	LOC102361424	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a. (355 aa)
	RYR2	Ryanodine receptor 2b (cardiac). (3465 aa)
	LOC102359168	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	MEF2C	Myocyte enhancer factor 2C. (462 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	RRAS2	RAS related 2. (202 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (552 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (251 aa)
	LOC102345989	Uncharacterized protein. (92 aa)
	SLC8A2	Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (914 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (783 aa)
	SLC8A3	Solute carrier family 8 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (589 aa)
	MYL2	Myosin light chain 2. (148 aa)
	CALML4	Calmodulin like 4. (165 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	LOC102356108	Uncharacterized protein. (208 aa)
	RRAS	RAS related. (174 aa)
	ADCY6	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
	GNG3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	GNAI3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
	LOC102354490	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	PLIN1	Perilipin 1. (526 aa)
	KLF2	Kruppel-like factor 2a. (388 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	RYR1	Ryanodine receptor 1. (5024 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
	CALML6	Calmodulin like 6. (160 aa)
	GNB1	G protein subunit beta 1. (340 aa)
	M3XGG2_LATCH	5-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (141 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)
	M3XIR5_LATCH	Uncharacterized protein. (217 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	GNGT2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	ACTG2	ENSLACP00000005571	ENSLACP00000004482	Uncharacterized protein.	Actin gamma 2, smooth muscle.	0.900
ACTA2	MYL2	ENSLACP00000005571	ENSLACP00000017426	Uncharacterized protein.	Myosin light chain 2.	0.453
ACTG2	ACTA2	ENSLACP00000004482	ENSLACP00000005571	Actin gamma 2, smooth muscle.	Uncharacterized protein.	0.900
ADCY4	ADCY5-2	ENSLACP00000004616	ENSLACP00000006513	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.962
ADCY4	ADCY6	ENSLACP00000004616	ENSLACP00000019614	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.971
ADCY4	ADCY8	ENSLACP00000004616	ENSLACP00000011649	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.949
ADCY4	ADCY9	ENSLACP00000004616	ENSLACP00000007634	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.960
ADCY4	GNAI1	ENSLACP00000004616	ENSLACP00000008403	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.944
ADCY4	GNAI3	ENSLACP00000004616	ENSLACP00000020114	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.944
ADCY4	GNB1	ENSLACP00000004616	ENSLACP00000021768	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 1.	0.772
ADCY4	GNG12	ENSLACP00000004616	ENSLACP00000000396	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.778
ADCY4	GNG2	ENSLACP00000004616	ENSLACP00000018370	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.828
ADCY4	GNG3	ENSLACP00000004616	ENSLACP00000019996	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.790
ADCY4	GNG7	ENSLACP00000004616	ENSLACP00000007654	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.784
ADCY4	GNG8	ENSLACP00000004616	ENSLACP00000009764	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.787
ADCY4	GNGT2	ENSLACP00000004616	ENSLACP00000023057	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.818
ADCY4	LOC102359168	ENSLACP00000004616	ENSLACP00000013280	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.739
ADCY4	LOC102361424	ENSLACP00000004616	ENSLACP00000013070	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	0.944
ADCY4	LOC102362951	ENSLACP00000004616	ENSLACP00000007730	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.920
ADCY4	LOC102365300	ENSLACP00000004616	ENSLACP00000002000	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.790