STRINGSTRING
VCL VCL ITGB6 ITGB6 ITGAV ITGAV TNR TNR BIRC2 BIRC2 ITGB1 ITGB1 COL9A1 COL9A1 ITGB8 ITGB8 LOC102364341 LOC102364341 LOC102354262 LOC102354262 VAV3 VAV3 ARHGAP5 ARHGAP5 LOC102354291 LOC102354291 ITGA1 ITGA1 COL1A2 COL1A2 LOC102367471 LOC102367471 MAPK9 MAPK9 FLNA FLNA LOC102352251 LOC102352251 PDGFB PDGFB LAMC1 LAMC1 THBS2 THBS2 PRKCB PRKCB COMP COMP LAMB4 LAMB4 LOC102349081 LOC102349081 SOS1 SOS1 ITGA3 ITGA3 LOC102348524 LOC102348524 PRKCA PRKCA AKT1 AKT1 MYL5 MYL5 JUN JUN ITGA8 ITGA8 ITGA6 ITGA6 LOC102351732 LOC102351732 PTEN PTEN LAMB1 LAMB1 MAP2K1 MAP2K1 SRC SRC PAK5 PAK5 H3AD77_LATCH H3AD77_LATCH SHC2 SHC2 RAF1 RAF1 IGF1R IGF1R PIP5K1A PIP5K1A LOC102348007 LOC102348007 FLNC FLNC PAK1 PAK1 LOC102365826 LOC102365826 THBS3 THBS3 MAPK10 MAPK10 PDGFRA PDGFRA PPP1CA PPP1CA LOC102359594 LOC102359594 KDR KDR LOC102348817 LOC102348817 TLN1 TLN1 H3ANZ1_LATCH H3ANZ1_LATCH SHC3 SHC3 ARHGAP35 ARHGAP35 COL1A1 COL1A1 PPP1CB PPP1CB COL4A6 COL4A6 LOC102346545 LOC102346545 SHC1 SHC1 VAV1 VAV1 GSK3B GSK3B RAP1B RAP1B VWF VWF SHC4 SHC4 CAV2 CAV2 CAV1 CAV1 FYN FYN PARVA PARVA CRKL CRKL COL6A1-2 COL6A1-2 PIK3CB PIK3CB CCND1 CCND1 RAC1 RAC1 MYL7 MYL7 FLNB FLNB MET MET LOC102361405 LOC102361405 LOC102345953 LOC102345953 DOCK1 DOCK1 ITGA2 ITGA2 PIK3R1 PIK3R1 COL4A1 COL4A1 COL6A2 COL6A2 TLN2 TLN2 MAPK1 MAPK1 ITGA9 ITGA9 LOC102360711 LOC102360711 ITGA4 ITGA4 PIP5K1B PIP5K1B PDGFRB PDGFRB CHAD CHAD LAMB2 LAMB2 CTNNB1 CTNNB1 MYL2 MYL2 PPP1CC PPP1CC PIK3CA PIK3CA COL9A2 COL9A2 ITGA11 ITGA11 ROCK2 ROCK2 VEGFD VEGFD MYL9 MYL9 CDC42 CDC42 LAMA3 LAMA3 ITGB7 ITGB7 LAMC3 LAMC3 RHOA RHOA ACTB ACTB COL9A3 COL9A3 FLT1 FLT1 ITGA10 ITGA10 LOC102363355 LOC102363355 THBS1 THBS1 CAV3 CAV3 PAK4 PAK4 HRAS HRAS RAP1A RAP1A MAPK8 MAPK8 LAMB3 LAMB3 PGF PGF COL2A1 COL2A1 VTN VTN RAC3 RAC3 ACTN1 ACTN1 PDGFA PDGFA RELN RELN PDGFD PDGFD LAMC2 LAMC2 VEGFC VEGFC AKT3 AKT3 FLT4 FLT4 IGF1 IGF1 HGF HGF LOC102352006 LOC102352006 PDGFC PDGFC PDPK1 PDPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VCLVinculin. (832 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (675 aa)
ITGAVIntegrin_alpha2 domain-containing protein. (597 aa)
TNRTenascin R. (992 aa)
BIRC2Baculoviral IAP repeat containing 2. (616 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (822 aa)
COL9A1LAM_G_DOMAIN domain-containing protein. (442 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (637 aa)
LOC102364341Uncharacterized protein. (271 aa)
LOC102354262Mitogen-activated protein kinase. (330 aa)
VAV3Si:ch73-383g2.1. (488 aa)
ARHGAP5Rho GTPase activating protein 5. (1303 aa)
LOC102354291Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (169 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1185 aa)
COL1A2Collagen type I alpha 2 chain. (1367 aa)
LOC102367471Uncharacterized protein; Belongs to the cyclin family. (292 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
FLNAFilamin A. (2637 aa)
LOC102352251Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (460 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
LAMC1Laminin subunit gamma 1. (1472 aa)
THBS2Uncharacterized protein. (1177 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
COMPUncharacterized protein. (740 aa)
LAMB4Laminin subunit beta 4. (1857 aa)
LOC102349081Integrin beta; Belongs to the integrin beta chain family. (570 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1012 aa)
LOC102348524Uncharacterized protein. (193 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (577 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (478 aa)
MYL5Myosin light chain 5. (188 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1048 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1077 aa)
LOC102351732Uncharacterized protein. (192 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
LAMB1Laminin subunit beta 1. (1398 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (396 aa)
SRCTyrosine-protein kinase. (535 aa)
PAK5Non-specific serine/threonine protein kinase. (740 aa)
H3AD77_LATCHJunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
SHC2SHC (Src homology 2 domain containing) transforming protein 2. (633 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
IGF1RInsulin like growth factor 1 receptor. (1170 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (878 aa)
LOC102348007Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (392 aa)
FLNCFilamin C. (2664 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
LOC102365826Uncharacterized protein. (868 aa)
THBS3Thrombospondin 3. (930 aa)
MAPK10Mitogen-activated protein kinase 10. (342 aa)
PDGFRAUncharacterized protein. (1094 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (344 aa)
LOC102359594Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
LOC102348817Uncharacterized protein. (1413 aa)
TLN1Talin 1. (2546 aa)
H3ANZ1_LATCHLAM_G_DOMAIN domain-containing protein. (870 aa)
SHC3SHC adaptor protein 3. (630 aa)
ARHGAP35Rho GTPase activating protein 35b. (1487 aa)
COL1A1Collagen type I alpha 1 chain. (1486 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
COL4A6Collagen type IV alpha 6 chain. (1654 aa)
LOC102346545Myosin, light chain 12, genome duplicate 2. (172 aa)
SHC1SHC adaptor protein 1. (602 aa)
VAV1Calponin-homology (CH) domain-containing protein. (85 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
VWFVon Willebrand factor. (2833 aa)
SHC4SHC adaptor protein 4. (617 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
FYNTyrosine-protein kinase. (537 aa)
PARVAParvin alpha. (372 aa)
CRKLCRK like proto-oncogene, adaptor protein. (219 aa)
COL6A1-2Uncharacterized protein. (370 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
RAC1Rac family small GTPase 1. (192 aa)
MYL7Myosin light chain 7. (182 aa)
FLNBFilamin B. (2605 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1385 aa)
LOC102361405PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (140 aa)
LOC102345953Cyclin D3; Belongs to the cyclin family. (292 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (873 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1129 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
COL6A2Collagen type VI alpha 2 chain. (1024 aa)
TLN2Talin 2. (1962 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
ITGA9Integrin subunit alpha 9. (480 aa)
LOC102360711PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (299 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1037 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (501 aa)
PDGFRBPlatelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
CHADChondroadherin. (361 aa)
LAMB2Laminin subunit beta 2. (1781 aa)
CTNNB1Catenin beta 1. (781 aa)
MYL2Myosin light chain 2. (148 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
COL9A2Collagen type IX alpha 2 chain. (691 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1136 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1462 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (341 aa)
MYL9Myosin light chain 9. (173 aa)
CDC42Cell division cycle 42. (156 aa)
LAMA3Laminin subunit alpha 3. (3364 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (778 aa)
LAMC3Laminin subunit gamma 3. (1573 aa)
RHOAUncharacterized protein. (193 aa)
ACTBUncharacterized protein. (376 aa)
COL9A3Collagen type IX alpha 3 chain. (682 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1177 aa)
LOC102363355ETS domain-containing protein. (380 aa)
THBS1Thrombospondin 1. (1170 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
PAK4Non-specific serine/threonine protein kinase. (704 aa)
HRASHRas proto-oncogene, GTPase. (193 aa)
RAP1ARAP1A, member of RAS oncogene family b. (185 aa)
MAPK8Mitogen-activated protein kinase. (437 aa)
LAMB3Laminin subunit beta 3. (1160 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (132 aa)
COL2A1Collagen type II alpha 1 chain. (1488 aa)
VTNVitronectin b. (492 aa)
RAC3Rac family small GTPase 3. (148 aa)
ACTN1Uncharacterized protein. (890 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (197 aa)
RELNReelin. (3462 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (369 aa)
LAMC2Uncharacterized protein. (1189 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (410 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1394 aa)
IGF1Insulin like growth factor 1. (136 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (720 aa)
LOC102352006Uncharacterized protein. (163 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (243 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (563 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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