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PLCB4 PLCB4 LOC102345654 LOC102345654 HTR2A HTR2A LOC102354262 LOC102354262 HTR2B HTR2B LOC102345731 LOC102345731 PDGFB PDGFB HTR2C HTR2C GRM1 GRM1 PRKCB PRKCB SOS1 SOS1 ADCY4 ADCY4 TUBB6 TUBB6 PRKCA PRKCA TUBB4B TUBB4B TUBB4A TUBB4A ADCY5-2 ADCY5-2 GUCY1A1 GUCY1A1 MAP2K1 MAP2K1 SRC SRC ADCY9 ADCY9 LOC102359416 LOC102359416 LOC102362951 LOC102362951 RAF1 RAF1 LOC102361922 LOC102361922 LOC102346946 LOC102346946 GNAI1 GNAI1 LOC102347483 LOC102347483 TUBB3 TUBB3 GJA1 GJA1 PDGFRA PDGFRA LOC102358088 LOC102358088 MAP2K2 MAP2K2 ADCY8 ADCY8 PLCB1 PLCB1 ADRB1 ADRB1 H3ARU2_LATCH H3ARU2_LATCH H3AS44_LATCH H3AS44_LATCH LOC102365599 LOC102365599 GJD2 GJD2 LOC102361424 LOC102361424 LOC102361824 LOC102361824 LOC102367099 LOC102367099 PRKACB PRKACB MAP2K5 MAP2K5 GNAS GNAS LPAR1 LPAR1 MAPK1 MAPK1 PDGFRB PDGFRB TUBB1 TUBB1 TUBB TUBB ITPR3 ITPR3 ADCY6 ADCY6 LOC102349899 LOC102349899 DRD1 DRD1 GNAI3 GNAI3 LOC102362449 LOC102362449 LOC102366134 LOC102366134 DRD2 DRD2 HRAS HRAS NRAS NRAS TJP1 TJP1 TUBA1C TUBA1C TUBA1B TUBA1B LOC102347472 LOC102347472 CDK1 CDK1 PDGFA PDGFA PDGFD PDGFD KRAS KRAS PDGFC PDGFC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB4Phosphoinositide phospholipase C. (919 aa)
LOC102345654Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (358 aa)
HTR2A5-hydroxytryptamine receptor 2A. (469 aa)
LOC102354262Mitogen-activated protein kinase. (330 aa)
HTR2B5-hydroxytryptamine receptor 2B. (474 aa)
LOC102345731Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
HTR2C5-hydroxytryptamine receptor 2C; Belongs to the G-protein coupled receptor 1 family. (342 aa)
GRM1Glutamate metabotropic receptor 1. (1167 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1092 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (577 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
TUBB4ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ADCY5-2AC_N domain-containing protein. (323 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1298 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (396 aa)
SRCTyrosine-protein kinase. (535 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1340 aa)
LOC102359416Uncharacterized protein. (359 aa)
LOC102362951Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
LOC102361922Dopamine receptor D2 like; Belongs to the G-protein coupled receptor 1 family. (448 aa)
LOC102346946Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
GNAI1G protein subunit alpha i1. (326 aa)
LOC102347483Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (475 aa)
TUBB3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the tubulin family. (771 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (383 aa)
PDGFRAUncharacterized protein. (1094 aa)
LOC102358088Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (663 aa)
MAP2K2Mitogen-activated protein kinase kinase 2a. (301 aa)
ADCY8AC_N domain-containing protein. (266 aa)
PLCB1Phosphoinositide phospholipase C. (1034 aa)
ADRB1Adrenoceptor beta 1. (394 aa)
H3ARU2_LATCHUncharacterized protein. (152 aa)
H3AS44_LATCHTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (471 aa)
LOC102365599Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (464 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (304 aa)
LOC102361424Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a. (355 aa)
LOC102361824cGMP-dependent protein kinase. (761 aa)
LOC102367099Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (473 aa)
PRKACBUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
GNASGNAS complex locus. (377 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (346 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
PDGFRBPlatelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (381 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
ADCY6Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
LOC102349899Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (453 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
LOC102362449Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
LOC102366134Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (300 aa)
DRD2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
HRASHRas proto-oncogene, GTPase. (193 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1782 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (463 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (462 aa)
LOC102347472Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (197 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (369 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (243 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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