(32 nodes) RIG-I-like receptor signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102363910	Uncharacterized protein. (634 aa)
	DDX58	DExD/H-box helicase 58. (944 aa)
	OTUD5	OTU deubiquitinase 5. (534 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (145 aa)
	MAPK14	Mitogen-activated protein kinase. (399 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (539 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	STING1	Uncharacterized protein. (380 aa)
	LOC102363090	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (97 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (700 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1408 aa)
	FADD	Fas associated via death domain. (193 aa)
	MAPK10	Mitogen-activated protein kinase 10. (342 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (710 aa)
	LOC102359628	Uncharacterized protein. (543 aa)
	IFIH1	Interferon induced with helicase C domain 1. (731 aa)
	LOC102359899	Uncharacterized protein. (282 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	TRADD	Death domain-containing protein. (313 aa)
	MAPK11	Mitogen-activated protein kinase. (361 aa)
	MAPK12	Uncharacterized protein. (103 aa)
	RNF135	Uncharacterized protein. (548 aa)
	AZI2	5-azacytidine induced 2. (394 aa)
	TKFC	Triokinase and FMN cyclase. (582 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (298 aa)
	NLRX1	NLR family member X1. (855 aa)
	NFKBIB	NFKB inhibitor beta. (397 aa)
	MAPK8	Mitogen-activated protein kinase. (437 aa)
	TANK	Uncharacterized protein. (72 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSLACP00000001446	ENSLACP00000015035	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	DDX58	ENSLACP00000001446	ENSLACP00000000461	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExD/H-box helicase 58.	0.935
ATG12	FADD	ENSLACP00000001446	ENSLACP00000009943	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Fas associated via death domain.	0.719
ATG12	IFIH1	ENSLACP00000001446	ENSLACP00000012995	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon induced with helicase C domain 1.	0.742
ATG12	NLRX1	ENSLACP00000001446	ENSLACP00000020273	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.551
ATG5	ATG12	ENSLACP00000015035	ENSLACP00000001446	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CASP10	ENSLACP00000015035	ENSLACP00000002069	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 10; Belongs to the peptidase C14A family.	0.542
ATG5	DDX58	ENSLACP00000015035	ENSLACP00000000461	Autophagy protein 5; Involved in autophagic vesicle formation.	DExD/H-box helicase 58.	0.935
ATG5	FADD	ENSLACP00000015035	ENSLACP00000009943	Autophagy protein 5; Involved in autophagic vesicle formation.	Fas associated via death domain.	0.794
ATG5	IFIH1	ENSLACP00000015035	ENSLACP00000012995	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon induced with helicase C domain 1.	0.737
ATG5	NLRX1	ENSLACP00000015035	ENSLACP00000020273	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.562
AZI2	CHUK	ENSLACP00000019553	ENSLACP00000007128	5-azacytidine induced 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.577
AZI2	IKBKE	ENSLACP00000019553	ENSLACP00000012245	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.861
AZI2	TANK	ENSLACP00000019553	ENSLACP00000023142	5-azacytidine induced 2.	Uncharacterized protein.	0.906
CASP10	ATG5	ENSLACP00000002069	ENSLACP00000015035	Caspase 10; Belongs to the peptidase C14A family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.542
CASP10	FADD	ENSLACP00000002069	ENSLACP00000009943	Caspase 10; Belongs to the peptidase C14A family.	Fas associated via death domain.	0.996
CASP10	TRADD	ENSLACP00000002069	ENSLACP00000017534	Caspase 10; Belongs to the peptidase C14A family.	Death domain-containing protein.	0.990
CASP10	TRAF2	ENSLACP00000002069	ENSLACP00000011356	Caspase 10; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.655
CASP10	TRAF3	ENSLACP00000002069	ENSLACP00000010314	Caspase 10; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.535
CASP10	TRAF6	ENSLACP00000002069	ENSLACP00000003556	Caspase 10; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.577